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Epidermal Growth Factor Receptor Gene Mutation in Pleural Lavage Cytology Findings of Primary Lung Adenocarcinoma Cases
- Source :
- Annals of Thoracic and Cardiovascular Surgery. 24:1-5
- Publication Year :
- 2018
- Publisher :
- Editorial Committee of Annals of Thoracic and Cardiovascular Surgery, 2018.
-
Abstract
- Purpose In the present study, we examined the relationship between intraoperative pleural lavage cytology findings and presence of epidermal growth factor receptor (EGFR) gene mutations. Methods We investigated 160 patients who underwent surgical treatment for primary lung adenocarcinoma at our hospital from January 2011 to December 2013 to determine the presence of EGFR gene mutations and pleural lavage cytology. Results In all, 52 subjects (31.5%) were positive EGFR gene mutations, of whom 38 were found to possess the Exon 21 L858R mutation. Intraoperative pleural lavage cytology examinations were performed in 160 subjects and 12 had positive results, of whom 6 were positive for EGFR gene mutations, which was the Exon 21 L858R mutation in all. In a comparison between subjects possessing the Exon 21 L858R mutation and those negative for EGFR gene mutations, lavage cytology-positive (p = 0.02) and vascular infiltration-negative (p = 0.01) were characteristics of the Exon 21 L868R mutation-positive group. Conclusion Subjects positive for the EGFR Exon 21 L858R mutation had a higher positive rate of intraoperative pleural lavage cytology than those not possessing EGFR mutations.
- Subjects :
- Male
Pathology
Lung Neoplasms
DNA Mutational Analysis
030204 cardiovascular system & hematology
Gene mutation
Exon
0302 clinical medicine
Japan
Risk Factors
Cytology
Epidermal growth factor receptor
Aged, 80 and over
integumentary system
biology
Gastroenterology
Exons
General Medicine
Middle Aged
ErbB Receptors
Phenotype
medicine.anatomical_structure
030220 oncology & carcinogenesis
Adenocarcinoma
Female
Original Article
Cardiology and Cardiovascular Medicine
Adult
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Adenocarcinoma of Lung
03 medical and health sciences
Biomarkers, Tumor
medicine
Humans
Genetic Predisposition to Disease
Therapeutic Irrigation
Lung cancer
Aged
Neoplasm Staging
Retrospective Studies
Lung
business.industry
medicine.disease
respiratory tract diseases
Egfr mutation
Mutation
biology.protein
Surgery
Neoplasm Grading
business
Subjects
Details
- ISSN :
- 21861005 and 13411098
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Annals of Thoracic and Cardiovascular Surgery
- Accession number :
- edsair.doi.dedup.....d51d9bef81b7bb2698ef1cfc1abcd4a5