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The effect of sorafenib treatment on the diabetic status of patients with renal cell or hepatocellular carcinoma
- Source :
- Future Oncology. 8:1051-1057
- Publication Year :
- 2012
- Publisher :
- Future Medicine Ltd, 2012.
-
Abstract
- Aim: To evaluate the effect of sorafenib on the glucose tolerance and diabetic status of patients with metastatic renal cell carcinoma (RCC) or advanced hepatocellular carcinoma (HCC). Materials & methods: Eighty patients with metastatic RCC or advanced HCC received 400 mg sorafenib twice daily for an average of approximately 8 and 5 months, respectively; 22 had diabetes mellitus and three had prediabetes. Results: One of 55 nondiabetic patients, and one of three patients with impaired fasting glucose or impaired glucose tolerance developed diabetes mellitus, one of 12 patients on oral antihyperglycemic agents switched to insulin and no patient treated with insulin needed to increase their dose. Conclusion: Sorafenib has the potential to be a feasible and safe treatment option for patients with advanced HCC or metastatic RCC and comorbid diabetes mellitus or prediabetes.
- Subjects :
- Niacinamide
Oncology
Sorafenib
Cancer Research
medicine.medical_specialty
Carcinoma, Hepatocellular
Pyridines
medicine.medical_treatment
Antineoplastic Agents
Comorbidity
urologic and male genital diseases
Gastroenterology
Impaired glucose tolerance
Renal cell carcinoma
Internal medicine
Diabetes mellitus
Diabetes Mellitus
medicine
Humans
Prediabetes
Neoplasm Metastasis
Carcinoma, Renal Cell
neoplasms
business.industry
Phenylurea Compounds
Insulin
Benzenesulfonates
Liver Neoplasms
General Medicine
medicine.disease
Impaired fasting glucose
Kidney Neoplasms
female genital diseases and pregnancy complications
digestive system diseases
Treatment Outcome
Hepatocellular carcinoma
business
medicine.drug
Subjects
Details
- ISSN :
- 17448301 and 14796694
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Future Oncology
- Accession number :
- edsair.doi.dedup.....d51d5bb57cb0a01db1a754583beb759c