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ABHD11, a new diacylglycerol lipase involved in weight gain regulation
- Source :
- PLoS ONE, Vol 15, Iss 6, p e0234780 (2020), PLoS ONE
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- Obesity epidemic continues to spread and obesity rates are increasing in the world. In addition to public health effort to reduce obesity, there is a need to better understand the underlying biology to enable more effective treatment and the discovery of new pharmacological agents. Abhydrolase domain-containing protein 11 (ABHD11) is a serine hydrolase enzyme, localized in mitochondria, that can synthesize the endocannabinoid 2-arachidonoyl glycerol (2AG) in vitro. In vivo preclinical studies demonstrated that knock-out ABHD11 mice have a similar 2AG level as WT mice and exhibit a lean metabolic phenotype. Such mice resist to weight gain in Diet Induced Obesity studies (DIO) and display normal biochemical plasma parameters. Metabolic and transcriptomic analyses on serum and tissues of ABHD11 KO mice from DIO studies show a modulation in bile salts associated with reduced fat intestinal absorption. These data suggest that modulating ABHD11 signaling pathway could be of therapeutic value for the treatment of metabolic disorders.
- Subjects :
- 0301 basic medicine
Diacylglycerol lipase
Physiology
Hydrolases
medicine.medical_treatment
Weight Gain
Biochemistry
Intestinal absorption
Feces
Gene Knockout Techniques
Mice
0302 clinical medicine
Endocrinology
Mathematical and Statistical Techniques
Medicine and Health Sciences
Bile
Insulin
Lipases
Energy-Producing Organelles
Multidisciplinary
biology
Statistics
Serine hydrolase
Genomics
Endocannabinoid system
Lipids
Mitochondria
Body Fluids
Enzymes
Physical Sciences
MCF-7 Cells
Medicine
Signal transduction
Cellular Structures and Organelles
Anatomy
Transcriptome Analysis
Signal Transduction
Research Article
medicine.medical_specialty
Science
Bioenergetics
Research and Analysis Methods
Gene Expression Regulation, Enzymologic
03 medical and health sciences
In vivo
Internal medicine
medicine
Genetics
Animals
Humans
Statistical Methods
Nutrition
Diabetic Endocrinology
Analysis of Variance
Gene Expression Profiling
Biology and Life Sciences
Proteins
Computational Biology
Cell Biology
Genome Analysis
In vitro
Hormones
Diet
030104 developmental biology
biology.protein
Enzymology
Serine Proteases
030217 neurology & neurosurgery
Mathematics
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d51141e8e4d92201c7362ba1515d0028