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Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis
- Source :
- Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
- Publication Year :
- 2020
-
Abstract
- Many pharmacologic agents were investigated for the effect to prevent delirium. We aimed to comprehensively compare the effect of the pharmacological interventions to prevent postoperative delirium. A Bayesian network meta-analysis of randomized trials was performed using random effects model. PubMed, the Cochrane Central Register of Controlled Trials, and Embase were searched on 20 January 2021. Randomized trials comparing the effect of a drug to prevent postoperative delirium with another drug or placebo in adult patients undergoing any kind of surgery were included. Primary outcome was the postoperative incidence of delirium. Eighty-six trials with 26,992 participants were included. Dexmedetomidine, haloperidol, and atypical antipsychotics significantly decreased the incidence of delirium than placebo [dexmedetomidine: odds ratio 0.51, 95% credible interval (CrI) 0.40–0.66, moderate quality of evidence (QOE); haloperidol: odds ratio 0.59, 95% CrI 0.37–0.95, moderate QOE; atypical antipsychotics: odds ratio 0.27, 95% CrI 0.14–0.51, moderate QOE]. Dexmedetomidine and atypical antipsychotics had the highest-ranking probabilities to be the best. However, significant heterogeneity regarding diagnostic time window as well as small study effects precludes firm conclusion.
- Subjects :
- Adult
medicine.medical_specialty
Science
Network Meta-Analysis
Placebo
Article
law.invention
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
Randomized controlled trial
030202 anesthesiology
law
Internal medicine
mental disorders
medicine
Haloperidol
Humans
030212 general & internal medicine
Dexmedetomidine
Randomized Controlled Trials as Topic
Preventive medicine
Disorders of consciousness
Multidisciplinary
business.industry
Incidence (epidemiology)
Delirium
Bayes Theorem
Odds ratio
Treatment Outcome
Pharmaceutical Preparations
Meta-analysis
Medicine
medicine.symptom
business
medicine.drug
Antipsychotic Agents
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....d50a337005c4022df17e2f799d0797ac