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In-ovo Newcastle disease virus vaccine strain TS09-C protects commercial chickens against Newcastle disease in the presence of maternally derived antibodies
- Source :
- Poultry Science, Poultry Science, Vol 99, Iss 5, Pp 2438-2443 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Maternally derived antibodies (MDA) substantially interfere with active immunity in post-hatch vaccination, although they provide early protection against disease through passive immunity in young chickens. Previously, Newcastle disease virus (NDV) strain TS09-C was demonstrated to be safe and immunogenic as in-ovo vaccine in specific-pathogen-free chickens. Here, we evaluated the safety, protective efficacy, and duration of clinical protection of the TS09-C virus as an in-ovo vaccine for commercial chickens in the presence of Maternally derived antibodies against NDV. This vaccine was safe in commercial chickens and provided at least 80% protection against a virulent NDV challenge for 3 mo, despite inducing a low hemagglutinin-inhibition titer. For commercial chickens, the protective efficacy of the in-ovo vaccination was markedly higher than that of posthatch vaccination, and the cellular immune response might play an important role in the higher protective efficacy of the in-ovo vaccine. The overall results indicate that the maternally derived antibodies against NDV do not significantly interfere with the ability of the in-ovo vaccine strain TS09-C to induce protective cellular immunity.
- Subjects :
- Cellular immunity
animal structures
Newcastle Disease
animal diseases
medicine.medical_treatment
Newcastle disease virus
Passive immunity
Biology
Antibodies, Viral
In ovo
Newcastle disease
Virus
Injections
03 medical and health sciences
Immune system
medicine
Animals
Poultry Diseases
lcsh:SF1-1100
Ovum
030304 developmental biology
maternally derived antibody
0303 health sciences
Vaccination
0402 animal and dairy science
Viral Vaccines
04 agricultural and veterinary sciences
General Medicine
Immunology, Health and Disease
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
040201 dairy & animal science
Virology
in-ovo vaccine
embryonic structures
biology.protein
Animal Science and Zoology
lcsh:Animal culture
Antibody
Chickens
strain TS09-C
Subjects
Details
- ISSN :
- 00325791
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Poultry Science
- Accession number :
- edsair.doi.dedup.....d508274ccd2b47fc8f6785b5e3af9c12