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Correction for Chiuppesi et al., 'Multiantigenic Modified Vaccinia Virus Ankara Vaccine Vectors To Elicit Potent Humoral and Cellular Immune Responses against Human Cytomegalovirus in Mice'
- Source :
- Journal of Virology. 93
- Publication Year :
- 2019
- Publisher :
- American Society for Microbiology, 2019.
-
Abstract
- As human cytomegalovirus (HCMV) is a common cause of disease in newborns and transplant recipients, developing an HCMV vaccine is considered a major public health priority. Yet an HCMV vaccine candidate remains elusive. Although the precise HCMV immune correlates of protection are unclear, both humoral and cellular immune responses have been implicated in protection against HCMV infection and disease. Here we describe a vaccine approach based on the well-characterized modified vaccinia virus Ankara (MVA) vector to stimulate robust HCMV humoral and cellular immune responses by an antigen combination composed of the envelope pentamer complex (PC), glycoprotein B (gB), and phosphoprotein 65 (pp65). We show that in mice, multiantigenic MVA vaccine vectors simultaneously expressing all five PC subunits, gB, and pp65 elicit potent complement-independent and complement-dependent HCMV neutralizing antibodies as well as mouse and human MHC-restricted, polyfunctional T cell responses by the individual antigens. In addition, we demonstrate that the PC/gB antigen combination of these multiantigenic MVA vectors can enhance the stimulation of humoral immune responses that mediate
- Subjects :
- Human cytomegalovirus
Immunology
Cytomegalovirus
Vaccinia virus
Biology
Antibodies, Viral
Microbiology
Virus
Viral Matrix Proteins
Cytomegalovirus Vaccines
Mice
chemistry.chemical_compound
Immune system
Viral Envelope Proteins
Pregnancy
Virology
medicine
Animals
Humans
Author Correction
Antigens, Viral
Immunity, Cellular
Base Sequence
Complement System Proteins
Phosphoproteins
medicine.disease
Antibodies, Neutralizing
Immunity, Humoral
Gene Expression Regulation
chemistry
Insect Science
Cytomegalovirus Infections
Female
Vaccinia
Partial support
Sequence Alignment
Sentence
Signal Transduction
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....d4fef73f63c862ce46925b39b35a3718