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Statins in the Prevention and Treatment of Heart Failure: a Review of the Evidence
- Source :
- Current Atherosclerosis Reports
- Publication Year :
- 2019
-
Abstract
- Purpose of Review: \ud We summarize the best evidence for statins in the prevention and treatment of heart failure.\ud \ud Recent Findings: \ud In patients with cardiovascular risk factors or established atherosclerotic cardiovascular disease (but without heart failure), statins reduce the risk of incident heart failure—mainly by preventing myocardial infarction although an additional benefit from reducing myocardial ischemia cannot be excluded. However, in patients with established heart failure, statins do not reduce the risk of cardiovascular death, which is mainly caused by pump failure and ventricular arrhythmias. Retrospective analyses, however, suggest that statins may reduce the rate of heart failure hospitalization and atherosclerotic events (which are proportionately much less common in these patients than heart failure hospitalization or death).\ud \ud Summary: \ud Statin therapy should probably be continued in patients with coronary artery disease developing heart failure, although the weak evidence and small benefit may not justify the use of this treatment in very elderly patients with a short life expectancy and in which polypharmacy is a problem.
- Subjects :
- Adult
medicine.medical_specialty
Statin
Adolescent
medicine.drug_class
Myocardial Infarction
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary artery disease
03 medical and health sciences
Young Adult
0302 clinical medicine
Internal medicine
medicine
Humans
In patient
030212 general & internal medicine
Myocardial infarction
cardiovascular diseases
Angiology
Aged
Polypharmacy
Aged, 80 and over
Heart Failure
Coronary disease
business.industry
Prevention
Cholesterol, LDL
Middle Aged
medicine.disease
Short life
Heart failure
Cardiology
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiology and Cardiovascular Medicine
business
Statin Drugs (M. Tikkanen, Section Editor)
Subjects
Details
- ISSN :
- 15346242 and 15233804
- Volume :
- 21
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Current atherosclerosis reports
- Accession number :
- edsair.doi.dedup.....d4ef661093d0fa0fa15b865a9615d3b6