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Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study

Authors :
María D. Mesa
Rosaura Leis
Augusto Anguita-Ruiz
Azahara I. Rupérez
Concepción M. Aguilera
Luis A. Moreno
Angel Gil
Francisco Jesus Llorente-Cantarero
Francisco Javier Aguilar-Gómez
Gloria Bueno
Rocío Vázquez-Cobela
Mercedes Gil-Campos
Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría
[Llorente-Cantarero,FJ] Department of Specific Didactics, Faculty of Education, Maimónides Institute of Biomedicine Research of Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain. [Llorente-Cantarero,FJ
Leis,R
Bueno,G
Anguita-Ruiz,A
Vázquez-Cobela,R
Moreno,LA
Gil,A
Aguilera,CM
Gil-Campos,M] CIBEROBN, (Physiopathology of Obesity and Nutrition) Institute of Health Carlos III (ISCIII), Madrid, Spain. [Aguilar-Gomez FJ
Gil-Campos,M] Metabolism and Investigation Unit, Reina Sofía University Hospital, Maimónides Institute of Biomedicine Research of Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain. [Leis,R
Vázquez-Cobela,R] Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, University of Santiago de Compostela, Clinic University Hospital of Santiago, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain. [Bueno,G] Pediatric Endocrinology Unit, Clinic University Hospital Lozano Blesa, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain. [Bueno,G
Rupérez,AI
Moreno,LA] GENUD Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria (IIS) Aragón, University of Zaragoza, Zaragoza, Spain. [Anguita-Ruiz,A
Mesa,MA
Aguilera,CM] Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology 'José Mataix', Center of Biomedical Research, University of Granada, Armilla, Granada, Spain. [Anguita-Ruiz,A
Aguilera,CM] Instituto de Investigación Biosanitaria ibs Granada, 18014 Granada, Spain.
This research was funded by the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) (PI11/02042, PI11/02059, PI11/01425
PI16/00871, PI16/01301, PI16/01205) and RETIC (Redes temáticas de investigación cooperativa) (Red SAMID RD12/0026/0015). The authors also acknowledge Instituto de Salud Carlos III for personal funding of A.A.R: Contratos i-PFIS: doctorados IIS-empresa en ciencias y tecnologías de la salud de la convocatoria 2017 de la Acción Estratégica en Salud 2013–2016 (IFI17/00048). Á.G. was funded by the Research Plan of the Vice-Rectorate of Research and Transfer of the University of Granada, Spain This paper will be included in F.J.A. doctorate, under the 'Biomedicine Program' at the University of Córdoba, Spain.
Source :
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, instname, Antioxidants, Zaguán: Repositorio Digital de la Universidad de Zaragoza, Universidad de Zaragoza, Antioxidants, Vol 10, Iss 320, p 320 (2021), Volume 10, Issue 2, Digibug. Repositorio Institucional de la Universidad de Granada, Zaguán. Repositorio Digital de la Universidad de Zaragoza, Digibug: Repositorio Institucional de la Universidad de Granada, Universidad de Granada (UGR), Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela, Universidad de Santiago de Compostela (USC)
Publication Year :
2021
Publisher :
MDPI, 2021.

Abstract

The World Health Organization has recommended performing at least 60 min a day of moderate-to-vigorous physical activity (MVPA) and reducing sedentarism in children and adolescents to offer significant health benefits and mitigate health risks. Physical fitness and sports practice seem to improve oxidative stress (OS) status during childhood. However, to our knowledge, there are no data regarding the influence of objectively-measured physical activity (PA) and sedentarism on OS status in children and adolescents. The present study aimed to evaluate the influence of moderate and vigorous PA and sedentarism on OS and plasma total antioxidant capacity (TAC) in a selected Spanish population of 216 children and adolescents from the GENOBOX study. PA (light, moderate, and vigorous) and sedentarism (i.e., sedentary time (ST)) were measured by accelerometry. A Physical Activity-Sedentarism Score (PASS) was developed integrating moderate and vigorous PA and ST levels. Urinary 8-hydroxy-20-deoxyguanosine (8-OHdG) and isoprostane F2 (F2-IsoPs), as markers of OS, were determined by ELISA; and TAC was estimated by colorimetry using an antioxidant kit. A higher PASS was associated with lower plasma TAC and urinary 8-OHdG and F2-IsoPs, showing a better redox profile. Reduced OS markers (8-OHdG and F2-IsoPs) in children with higher PASS may diminish the need of maintaining high concentrations of antioxidants in plasma during rest to achieve redox homeostasis.<br />Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) PI11/02042 PI11/02059 PI11/01425 PI16/00871 PI16/01301 PI16/01205<br />RETIC (Redes temáticas de investigación cooperativa) Red SAMID RD12/0026/0015<br />Instituto de Salud Carlos III European Commission IFI17/00048<br />Research Plan of the Vice-Rectorate of Research and Transfer of the University of Granada, Spain

Subjects

Subjects :
Antioxidant
Isoprostane
8-hydroxy-2′-deoxyguanosine
Physiology
medicine.medical_treatment
Clinical Biochemistry
Physical fitness
physical activity
medicine.disease_cause
Biochemistry
Acelerometría
chemistry.chemical_compound
0302 clinical medicine
Accelerometry
oxidative stress
030212 general & internal medicine
Isoprostane F2α
Plasma total antioxidant capacity
Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings]
Health Care::Health Care Economics and Organizations::Organizations::International Agencies::United Nations::World Health Organization [Medical Subject Headings]
Total plasma
plasma total antioxidant capacity
Estrés oxidativo
Ejercicio físico
isoprostane F2
Antioxidant capacity
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Titrimetry::Colorimetry [Medical Subject Headings]
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunoassay::Immunoenzyme Techniques::Enzyme-Linked Immunosorbent Assay [Medical Subject Headings]
8-Hidroxi-2'-Desoxicoguanosina
medicine.medical_specialty
Physical activity
Article
03 medical and health sciences
Internal medicine
isoprostane F2α
Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Antioxidants [Medical Subject Headings]
medicine
accelerometry
Pysical activity
Molecular Biology
Redox homeostasis
business.industry
lcsh:RM1-950
030229 sport sciences
Cell Biology
8-hydroxy-20-deoxyguanosine
Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Physical Fitness [Medical Subject Headings]
lcsh:Therapeutics. Pharmacology
chemistry
Oxidative stress
business

Details

Database :
OpenAIRE
Journal :
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, instname, Antioxidants, Zaguán: Repositorio Digital de la Universidad de Zaragoza, Universidad de Zaragoza, Antioxidants, Vol 10, Iss 320, p 320 (2021), Volume 10, Issue 2, Digibug. Repositorio Institucional de la Universidad de Granada, Zaguán. Repositorio Digital de la Universidad de Zaragoza, Digibug: Repositorio Institucional de la Universidad de Granada, Universidad de Granada (UGR), Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela, Universidad de Santiago de Compostela (USC)
Accession number :
edsair.doi.dedup.....d4dcffbb85c287365c97a540124f3298

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