Back to Search
Start Over
Promises and Pitfalls of Intracellular Delivery of Proteins
- Source :
- Bioconjugate Chemistry
- Publication Year :
- 2014
- Publisher :
- American Chemical Society (ACS), 2014.
-
Abstract
- The direct delivery of functional proteins into the cell cytosol is a key issue for protein therapy, with many current strategies resulting in endosomal entrapment. Protein delivery to the cytosol is challenging due to the high molecular weight and the polarity of therapeutic proteins. Here we review strategies for the delivery of proteins into cells, including cell-penetrating peptides, virus-like particles, supercharged proteins, nanocarriers, polymers, and nanoparticle-stabilized nanocapsules. The advantages and disadvantages of these approaches including cytosolar delivery are compared and contrasted, with promising pathways forward identified.
- Subjects :
- Pharmacology
Chemistry
Endosome
Extramural
Organic Chemistry
Cell
Intracellular Space
Biomedical Engineering
Proteins
Pharmaceutical Science
Bioengineering
Nanocapsules
Cell biology
Cytosol
Drug Delivery Systems
medicine.anatomical_structure
Proteins metabolism
medicine
Animals
Humans
Topical Review
Nanocarriers
Intracellular
Biotechnology
Subjects
Details
- ISSN :
- 15204812 and 10431802
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Bioconjugate Chemistry
- Accession number :
- edsair.doi.dedup.....d4d90355309c88a2c4eba7126019d5ef