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Markers of neuroinflammation influence measures of cortical thickness in bipolar depression
- Source :
- Psychiatry Research-Neuroimaging, 285, 64-66. Elsevier Ireland Ltd, Psychiatry Research: Neuroimaging
- Publication Year :
- 2019
- Publisher :
- Elsevier Ireland Ltd, 2019.
-
Abstract
- We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thickness and fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negatively correlated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α, Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and with lower BOLD responses to negative stimuli. Markers of immune activation are associated with measures of brain structural and functional integrity in bipolar depression.
- Subjects :
- Adult
Male
Radiology, Nuclear Medicine and Imaging
Bipolar Disorder
Decision Making
Neuroscience (miscellaneous)
Grey matter
Emotional processing
Gyrus Cinguli
Young Adult
03 medical and health sciences
0302 clinical medicine
Inferior temporal gyrus
medicine
Humans
Radiology, Nuclear Medicine and imaging
Cytokine
Neuroinflammation
Anterior cingulate cortex
Depression
business.industry
Organ Size
Middle Aged
Magnetic Resonance Imaging
030227 psychiatry
Peripheral
Psychiatry and Mental health
Functional integrity
medicine.anatomical_structure
Psychiatry and Mental Health
Female
Inflammation Mediators
business
Neuroscience
Biomarkers
030217 neurology & neurosurgery
Parahippocampal gyrus
Immune activation
Subjects
Details
- ISSN :
- 18727506 and 09254927
- Volume :
- 285
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research - Neuroimaging
- Accession number :
- edsair.doi.dedup.....d4d71b58a953e04c485f4a84e264ce49