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Genetic Structure of First Nation Communities in the Pacific Northwest
- Source :
- Human biology. 88(4)
- Publication Year :
- 2017
-
Abstract
- This study presents genetic data for nine Native American populations from northern North America. Analyses of genetic variation focus on the Pacific Northwest (PNW). Using mitochondrial, Y chromosomal, and autosomal DNA variants, we aimed to more closely address the relationships of geography and language with present genetic diversity among the regional PNW Native American populations. Patterns of genetic diversity exhibited by the three genetic systems were consistent with our hypotheses: genetic variation was more strongly explained by geographic proximity than by linguistic structure. Our findings were corroborated through a variety on analytic approaches, with the unrooted trees for the three genetic systems consistently separating inland from coastal PNW populations. Furthermore, analyses of molecular variance support the trends exhibited by the unrooted trees, with geographic partitioning of PNW populations (FCT = 19.43%, p = 0.010 ± 0.009) accounting for over twice as much of the observed genetic variation as linguistic partitioning of the same populations (FCT = 9.15%, p = 0.193 ± 0.013). These findings demonstrate a consensus with previous PNW population studies examining the relationships of genome-wide variation, mitochondrial haplogroup frequencies, and skeletal morphology with geography and language.
- Subjects :
- 0301 basic medicine
First nation
Mitochondrial DNA
Northwestern United States
Population
Biology
DNA, Mitochondrial
03 medical and health sciences
Genetic variation
Genetics
Cluster Analysis
Humans
education
Genetics (clinical)
Ecology, Evolution, Behavior and Systematics
Phylogeny
education.field_of_study
Genetic diversity
Chromosomes, Human, Y
Geography
Ecology
Genetic Variation
Linguistics
Sequence Analysis, DNA
Emigration and Immigration
030104 developmental biology
Variation (linguistics)
Genetics, Population
Genetic structure
Indians, North American
Human mitochondrial DNA haplogroup
Subjects
Details
- ISSN :
- 15346617
- Volume :
- 88
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Human biology
- Accession number :
- edsair.doi.dedup.....d4d6163e09439d3337a8a04407df70c4