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Genital Bowen's Disease in a Bulgarian Patient: Complete Remission after Surgical Approach
- Source :
- Open Access Macedonian Journal of Medical Sciences, Open Access Macedonian Journal of Medical Sciences, Vol 5, Iss 4, Pp 545-546 (2017), Open Access Macedonian Journal of Medical Sciences; Vol 5 No 4 (2017): Jul 25 (OAMJMS) Global Dermatology-1; 545-546, Open Access Macedonian Journal of Medical Sciences; Vol 5, No 4 (2017): Jul 25 (OAMJMS) Global Dermatology-1; 545-546
- Publication Year :
- 2017
-
Abstract
- A 60-year-old male patient presented with complaints of persistent red to a brown-colored plaque on his scrotum, with duration of approximately three years. The patient had been treated with oral and topical antifungals for inguinal tinea for several months and after that with topical corticosteroids for eczema for several more months. None of the regimens achieved any therapeutic effect. The histopathological evaluation revealed the presence of atypical keratinocytes in all layers of the epidermis with the altered epidermal pattern, spread parabasal mitotic activity, without secondary satellites, multiple dyskeratotic cells and multinucleated cells. The diagnosis of an intraepithelial non-invasive squamous cell carcinoma, associated with koilocytic dysplasia and hyperplasia was made, meeting the criteria for Bowen disease. An elliptic surgical excision of the lesion was made, while the defect was closed with single stitches, with excellent therapeutic and aesthetic result. First described by John T. Bowen in 1912, Bowen disease (BD) represents a squamous cell carcinoma (SCC) in situ with the potential for significant lateral spread. Treatment options include the application of topical 5-flurorouracil cream – useful in non-hairy areas, imiquimod cream or destructive methods such as radiation, curettage, cryotherapy, laser ablation and photodynamic therapy, especially useful in nail bed involvement. Despite the early lesions, surgical excision is the preferred treatment option, regarding the potential malignant transformation risk.
- Subjects :
- medicine.medical_specialty
bowen
genital located
imiquimod
surgical approach
complete remission
medicine.medical_treatment
lcsh:Medicine
Imiquimod
Cryotherapy
Dermatology
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Scrotum
medicine
Bowen's disease
business.industry
Therapeutic effect
lcsh:R
General Medicine
Hyperplasia
medicine.disease
Curettage
Surgery
medicine.anatomical_structure
Dysplasia
030220 oncology & carcinogenesis
Clinical Image
Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 18579655
- Volume :
- 5
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Open access Macedonian journal of medical sciences
- Accession number :
- edsair.doi.dedup.....d4cf75dcf3399b3e10869605916535c6