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Predictors of health-related quality of life in patients treated with neck dissection for head and neck cancer
- Source :
- European Archives of Oto-Rhino-Laryngology. 274:4183-4193
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Patients with head and neck cancer can report reduced health-related quality of life several years after treatment. The aim of this study was to identify risk factors for reduced quality of life in patients up to 5 years following neck dissection. This cross-sectional study was conducted at two hospitals in Brisbane, Australia. Patients completed two measures of quality of life: the Neck Dissection Impairment Index (NDII), a region- and disease-specific tool, and the Assessment of Quality of Life-4 Domains, a general tool. Generalised linear modelling was used to determine which demographic and clinical variables were associated with quality of life. The cohort included n = 129 patients (71% male, median age 61, median 3 years since surgery). Positive nodal disease was associated with better quality of life on the NDII [e.g. N2 vs N0 coeff (95% CI) = 22.84 (7.33, 38.37)]. Worse quality of life was associated with adjuvant treatment [e.g. Independent Living domain model: surgery with chemoradiation vs surgery only coeff (95% CI) = -0.11 (-0.22, -0.01)]. Positive nodal disease was associated with better quality of life, which may be a reflection of response shift. Multimodality treatment leads to worse quality of life compared with surgery only.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
03 medical and health sciences
0302 clinical medicine
Quality of life
Internal medicine
Humans
Medicine
030223 otorhinolaryngology
Aged
business.industry
Head and neck cancer
Australia
Neck dissection
General Medicine
Middle Aged
medicine.disease
Combined Modality Therapy
Surgery
Radiation therapy
Cross-Sectional Studies
Treatment Outcome
Otorhinolaryngology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Cohort
Quality of Life
Neck Dissection
Female
Neurosurgery
business
Neck Dissection Impairment Index
Subjects
Details
- ISSN :
- 14344726 and 09374477
- Volume :
- 274
- Database :
- OpenAIRE
- Journal :
- European Archives of Oto-Rhino-Laryngology
- Accession number :
- edsair.doi.dedup.....d4cbee75824f849eb1e9937444a9d8e1