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Prognostic Factors for Endometrial and Cervical Cancers of Uterus Treated With Immune-cell Therapy: A Retrospective Study
- Source :
- Anticancer Research. 40:4729-4740
- Publication Year :
- 2020
- Publisher :
- Anticancer Research USA Inc., 2020.
-
Abstract
- Background/aim In this retrospective study, we aimed to investigate the efficacy of immune-cell therapy using T lymphocytes activated in vitro with or without dendritic cell vaccination in combination with standard therapies in terms of the survival of patients with advanced or recurrent endometrial and cervical cancers of the uterus. Patients and methods A total of 187 patients with advanced or recurrent uterine cancer were enrolled in this study. The correlation between overall survival and various clinical factors was examined by univariate and multivariate analyses. Results Univariate analysis revealed that the prognosis was improved in uterine cancer patients who received immune-cell therapy without prior chemotherapy or without distant metastasis. Multivariate analysis demonstrated that the absence of prior chemotherapy for endometrial cancer and liver/lung metastasis of cervical cancer are indications for immune-cell therapy. Conclusion Survival benefit in uterine cancer patients could be potentially obtained by a combination of immune-cell therapy with other therapies.
- Subjects :
- Adult
Oncology
Cancer Research
medicine.medical_specialty
T-Lymphocytes
medicine.medical_treatment
Cell- and Tissue-Based Therapy
Uterus
Uterine Cervical Neoplasms
Disease-Free Survival
Cell therapy
Uterine cancer
Internal medicine
medicine
Humans
Aged
Retrospective Studies
Aged, 80 and over
Cervical cancer
Chemotherapy
Univariate analysis
business.industry
Endometrial cancer
Retrospective cohort study
General Medicine
Middle Aged
Prognosis
medicine.disease
Endometrial Neoplasms
Treatment Outcome
medicine.anatomical_structure
Uterine Neoplasms
Female
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....d4ca6c6b834b19637a2e859b119b9eb7