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Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum
- Source :
- Diagnostics, Vol 11, Iss 260, p 260 (2021), Diagnostics, Volume 11, Issue 2
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Pseudoxanthoma elasticum (PXE) is a rare multisystemic autosomal recessive connective tissue disease. In most cases, skin manifestations of PXE are the first to develop, followed later by severe ocular and cardiovascular complications. In our present study, in addition to dermoscopy, we introduced novel techniques, autofluorescence (AF) and diffuse reflectance (DR) imaging for the assessment of affected skin sites of five PXE patients. PXE-affected skin areas in most skin sites showed a previously observed pattern upon dermoscopic examination. With the novel imaging, PXE-affected skin lesions displayed high AF intensity. During our measurements, significantly higher mean, minimum and maximum AF intensity values were found in areas of PXE-affected skin when compared to uninvolved skin. Conversely, images acquired with the use of 660 and 940 nm illumination showed no mentionable difference. Our results demonstrate that AF imaging may be used in the in vivo diagnostics and quantification of the severity of the skin lesions of PXE patients. In addition, it is a safe, fast and cost-effective diagnostic method. AF imaging may be also used to objectively monitor the efficacy of the possible novel therapeutic approaches of PXE in the future.
- Subjects :
- Pathology
medicine.medical_specialty
Diagnostic methods
diagnosis
Uninvolved skin
Clinical Biochemistry
01 natural sciences
Article
autofluorescence imaging
calcification
010309 optics
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
diffuse reflectance imaging
0103 physical sciences
medicine
pseudoxanthoma elasticum
Skin manifestations
lcsh:R5-920
quantitative analysis
integumentary system
business.industry
LED
Non invasive
medicine.disease
Pseudoxanthoma elasticum
Connective tissue disease
Autofluorescence
dermoscopy
lcsh:Medicine (General)
business
Calcification
Subjects
Details
- ISSN :
- 20754418
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....d4aef0f33caf489b60c36309518fe61f