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Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank
- Source :
- Zhu, X, Ward, J, Cullen, B, Lyall, D M, Strawbridge, R J, Lyall, L M & Smith, D J 2021, ' Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank ', Translational Psychiatry, vol. 11, no. 1 . https://doi.org/10.1101/2020.06.29.20142984, https://doi.org/10.1038/s41398-021-01522-4, Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021), Translational Psychiatry
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- BackgroundAnhedonia is a core symptom of multiple psychiatric disorders and has been associated with changes in brain structure. Genome-wide association studies suggest that anhedonia is heritable with a polygenic architecture but few studies have explored the association between genetic loading for anhedonia - indexed by polygenic risk scores for anhedonia (PRS-anhedonia) - and structural brain imaging phenotypes. We investigated how anhedonia and polygenic risk for anhedonia were associated with brain structure within the UK Biobank cohort.MethodsBrain measures (including total grey/white matter volumes, subcortical volumes, cortical thickness and white matter integrity) were analysed in relation to the self-reported anhedonia phenotype and PRS-anhedonia for 17,492 participants (8,506 males and 8,986 females; mean age = 62.81 years, SD = 7.43), using linear mixed models and including mediation analyses.ResultsState anhedonia was significantly associated with smaller total grey matter volume (GMV), smaller volumes in thalamus and nucleus accumbens; as well as reduced cortical thickness within the paracentral gyrus, the opercular part of inferior frontal gyrus and the rostral anterior cingulate cortex. PRS-anhedonia was associated with reduced total GMV, increased total white matter volume and reduced white matter integrity; in addition to reduced cortical thickness within the parahippocampal cortex, the superior temporal gyrus and the insula cortex.ConclusionsBoth the state anhedonia phenotype and PRS-anhedonia were associated with differences in multiple brain structures/areas, including within reward-related circuits. These differences may represent vulnerability markers for psychopathology across a range of psychiatric disorders.
- Subjects :
- Male
0301 basic medicine
Anhedonia
Inferior frontal gyrus
Neurosciences. Biological psychiatry. Neuropsychiatry
Biology
Grey matter
behavioral disciplines and activities
Article
White matter
03 medical and health sciences
Cellular and Molecular Neuroscience
Superior temporal gyrus
0302 clinical medicine
Gyrus
Cortex (anatomy)
medicine
Humans
Gray Matter
Biological Psychiatry
Anterior cingulate cortex
Biological Specimen Banks
business.industry
Brain
Middle Aged
Magnetic Resonance Imaging
White Matter
United Kingdom
Psychiatry and Mental health
Phenotype
030104 developmental biology
medicine.anatomical_structure
behavior and behavior mechanisms
medicine.symptom
Psychiatric disorders
business
Insula
Neuroscience
Biomarkers
psychological phenomena and processes
030217 neurology & neurosurgery
Genome-Wide Association Study
RC321-571
Subjects
Details
- ISSN :
- 21583188
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Translational Psychiatry
- Accession number :
- edsair.doi.dedup.....d4aba2eaf7416dae35cc647a86c6137c