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Underexpression of miR-34a in Hepatocellular Carcinoma and Its Contribution towards Enhancement of Proliferating Inhibitory Effects of Agents Targeting c-MET
- Source :
- PLoS ONE, Vol 8, Iss 4, p e61054 (2013), PLoS ONE
- Publication Year :
- 2013
- Publisher :
- Public Library of Science (PLoS), 2013.
-
Abstract
- Aberrant expression of microRNA-34a (miR-34a) has been reported to be involved in the tumorigenesis and progression of various classes of malignancies. However, its role in hepatocellular carcinoma (HCC) has not been completely clarified. In the current study, we have investigated the clinical significance and the in vitro contribution of miR-34a on biological functions of human HCCs. miR-34a expression in eighty-three cases of HCC formalin-fixed paraffin-embedded (FFPE) tissues decreased significantly compared to that in the adjacent liver tissues (P
- Subjects :
- Male
Pathology
medicine.medical_treatment
lcsh:Medicine
Signal transduction
ERK signaling cascade
medicine.disease_cause
Biochemistry
Polymerase Chain Reaction
Metastasis
Targeted therapy
chemistry.chemical_compound
RNA interference
Molecular cell biology
Gastrointestinal Cancers
Basic Cancer Research
lcsh:Science
Aged, 80 and over
Multidisciplinary
Chemistry
Liver Neoplasms
Signaling cascades
Middle Aged
Proto-Oncogene Proteins c-met
Nucleic acids
Phenotype
Oncology
Hepatocellular carcinoma
Medicine
Epigenetics
Female
Research Article
Adult
medicine.medical_specialty
Carcinoma, Hepatocellular
C-Met
Signaling in cellular processes
Gastroenterology and Hepatology
Gastrointestinal Tumors
microRNA
Genetics
Cancer Detection and Diagnosis
medicine
Humans
Biology
Aged
DNA Primers
STAT signaling family
Cell growth
lcsh:R
Cancers and Neoplasms
Hepatocellular Carcinoma
HCCS
medicine.disease
MicroRNAs
Cancer research
RNA
lcsh:Q
Gene expression
Carcinogenesis
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d49df73374298e125104a1d43a299d6b