Loss of alpha globin genes is associated with improved microvascular function in patients with sickle cell anemia

Authors :: K. Reminy
Philippe Connes
Berenike Moeckesch
Lydia Doumdo
Christopher C Denton
Marie-Dominique Hardy-Dessources
Marie Petras
Thomas D. Coates
Sophie Antoine-Jonville
Benoit Tressières
Keyne Charlot
Nathalie Lemonne
Marc Romana
Maryse Etienne-Julan
Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134))
Institut National de la Transfusion Sanguine [Paris] (INTS)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université des Antilles (UA)-Université de Paris (UP)
Adaptation, Climat Tropical, Exercice et Santé (ACTES)
Université des Antilles (UA)
Source :: American Journal of Hematology, American Journal of Hematology, Wiley, 2021, 96 (5), ⟨10.1002/ajh.26126⟩
Publication Year :: 2021
Abstract: International audience

Subjects :: Adult
Erythrocyte Indices
Male
Adolescent
Anemia
[SDV]Life Sciences [q-bio]
Blood Pressure
Anemia, Sickle Cell
030204 cardiovascular system & hematology
Nitric Oxide
Body Mass Index
Fingers
03 medical and health sciences
Young Adult
0302 clinical medicine
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
alpha-Globins
alpha-Thalassemia
medicine
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Humans
In patient
Alpha globulin
Child
Gene
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
0303 health sciences
business.industry
Erythrocyte indices
Microcirculation
[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology
Hematology
Gene deletion
Middle Aged
medicine.disease
Sickle cell anemia
Vasodilation
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
Immunology
Multivariate Analysis
Female
business
Function (biology)
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Blood Flow Velocity
Gene Deletion

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