ColonialDifferentiation in Streptomyces coelicolor Depends on Translation of a SpecificCodon within the adpA Gene

We identified adpA as an araC -like regulatory gene needed for colonial morphogenesis in Streptomyces coelicolor and showed that its activity depended on a unique TTA triplet corresponding to the leucyl-tRNA gene ( bldA ). These findings partially explained the dependence of aerial mycelium formation on a rare tRNA that is postulated to have developmental control functions.