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Non-Alcoholic Steatohepatitis Decreases Microsomal Liver Function in the Absence of Fibrosis
- Source :
- Biomedicines, Biomedicines, Vol 8, Iss 546, p 546 (2020), Volume 8, Issue 12
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The incidence of non-alcoholic fatty liver disease (NAFLD) is rising across the globe, with the presence of steatohepatitis leading to a more aggressive clinical course. Currently, the diagnosis of non-alcoholic steatohepatitis (NASH) is based on histology, though with the high prevalence of NAFLD, a non-invasive method is needed. The 13C-aminopyrine breath test (ABT) evaluates the microsomal liver function and could be a potential candidate. We aimed to evaluate a potential change in liver function in NASH patients and to evaluate the diagnostic power of ABT to detect NASH. We performed a retrospective analysis on patients suspected of NAFLD who underwent a liver biopsy and ABT. 440 patients were included. ABT did not decrease in patients with isolated liver steatosis but decreased significantly in the presence of NASH without fibrosis and decreased even further with the presence of significant fibrosis. The predictive power of ABT as a single test for NASH was low but improved in combination with ALT and ultrasonographic steatosis. We conclude that microsomal liver function of patients with NASH is significantly decreased, even in the absence of fibrosis. The ABT is thus a valuable tool in assessing the presence of NASH<br />and could be used as a supplementary diagnostic tool in clinical practice.
- Subjects :
- medicine.medical_specialty
steatohepatitis
Medicine (miscellaneous)
aminopyrine
digestive system
Gastroenterology
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Fibrosis
Internal medicine
medicine
lcsh:QH301-705.5
microsomal
Breath test
medicine.diagnostic_test
business.industry
Pharmacology. Therapy
breath test
Incidence (epidemiology)
Fatty liver
NASH
nutritional and metabolic diseases
medicine.disease
digestive system diseases
lcsh:Biology (General)
liver function
030220 oncology & carcinogenesis
Liver biopsy
030211 gastroenterology & hepatology
Human medicine
Liver function
Steatohepatitis
Steatosis
business
Subjects
Details
- ISSN :
- 22279059
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Biomedicines
- Accession number :
- edsair.doi.dedup.....d4865f4262c3e6e3883eb530ea22309c