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Fast analysis of caffeine in beverages and drugs by paper spray tandem mass spectrometry
- Source :
- Analytical and Bioanalytical Chemistry. 408:3783-3787
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- A simple and fast method based on paper spray mass spectrometry for the determination of caffeine in commercial beverages and drugs has been developed; the analyses were carried out in MRM mode, monitoring the transitions m/z 195 → m/z 138 for caffeine and m/z 198 → m/z 140 for the labeled internal standard. To verify the reliability of the proposed approach, a spiked sample (soda drink and paracetamol tablet) with a known amount of caffeine has been prepared and analyzed by PS-MS, providing accuracy values about 100 %; the LOQ and LOD values were calculated at 1.2 and 1.6 μg/mL, respectively. Both beverages and drugs were also analyzed with the classic analytical method based on LC-UV measurements, showing consistent results between the two approaches, thus confirming the reliability of the developed ambient MS determination. Graphical Abstract The assay of caffeine by paper mass spectrometry.
- Subjects :
- Detection limit
Chromatography
Chemistry
010401 analytical chemistry
Selected reaction monitoring
Analytical chemistry
Reference Standards
010402 general chemistry
Mass spectrometry
Tandem mass spectrometry
01 natural sciences
Biochemistry
0104 chemical sciences
Analytical Chemistry
Beverages
chemistry.chemical_compound
Pharmaceutical Preparations
Limit of Detection
Tandem Mass Spectrometry
Caffeine
Quantitative assay
Spectrophotometry, Ultraviolet
Reference standards
Subjects
Details
- ISSN :
- 16182650 and 16182642
- Volume :
- 408
- Database :
- OpenAIRE
- Journal :
- Analytical and Bioanalytical Chemistry
- Accession number :
- edsair.doi.dedup.....d482e8703bf7a0a43a6dc7467249831b