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Measurement of lactate accumulation byin Vivo proton NMR spectroscopy during global cerebral ischemia in rats

Authors :
Thomas L. James
Max A. Keniry
Todd L. Richards
Brian T. Andrews
Elizabeth Murphy
Philip Weinstein
Bryan M. Pereira
Source :
Magnetic Resonance in Medicine. 5:353-357
Publication Year :
1987
Publisher :
Wiley, 1987.

Abstract

In vivo1H NMR spectral editing techniques were used to monitor cerebral lactate production during remotely controlled temporary forebrain ischemia in rats. The lactate/N-acetylaspartate (NAA) ratio correlated with survival after ischemia and subsequent reperfusion. The lactate/NAA ratio that predicted death after ischemia in rats was estimated to be approximately 1.3. © 1987 Academic Press, Inc.

Details

ISSN :
15222594 and 07403194
Volume :
5
Database :
OpenAIRE
Journal :
Magnetic Resonance in Medicine
Accession number :
edsair.doi.dedup.....d46e204e7a2e8c83c160fbcc857b7382
Full Text :
https://doi.org/10.1002/mrm.1910050406