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Author Correction:GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk
- Source :
- Pirastu, N, Joshi, P K, de Vries, P S, Cornelis, M C, McKeigue, P M, Keum, N, Franceschini, N, Colombo, M, Giovannucci, E L, Spiliopoulou, A, Franke, L, North, K E, Kraft, P, Morrison, A C, Esko, T & Wilson, J F 2018, ' Author Correction : GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk ', Nature Communications, vol. 9, no. 1, pp. 2536 . https://doi.org/10.1038/s41467-018-04857-7, Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018), Nature Communications
- Publication Year :
- 2018
-
Abstract
- Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50; however, the known genes explain little of the heritability. Here, we present the results of a genome-wide association study including more than 70,000 men, identifying 71 independently replicated loci, of which 30 are novel. These loci explain 38% of the risk, suggesting that MPB is less genetically complex than other complex traits. We show that many of these loci contain genes that are relevant to the pathology and highlight pathways and functions underlying baldness. Finally, despite only showing genome-wide genetic correlation with height, pathway-specific genetic correlations are significant for traits including lifespan and cancer. Our study not only greatly increases the number of MPB loci, illuminating the genetic architecture, but also provides a new approach to disentangling the shared biological pathways underlying complex diseases.
- Subjects :
- 0301 basic medicine
Male
Risk
Published Erratum
Science
General Physics and Astronomy
Genome-wide association study
Biology
Polymorphism, Single Nucleotide
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Surveys and Questionnaires
medicine
Humans
Genetic Predisposition to Disease
Prospective Studies
Author Correction
Multidisciplinary
Alopecia
General Chemistry
Heritability
medicine.disease
030104 developmental biology
Evolutionary biology
Susceptibility locus
Male-pattern baldness
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Pirastu, N, Joshi, P K, de Vries, P S, Cornelis, M C, McKeigue, P M, Keum, N, Franceschini, N, Colombo, M, Giovannucci, E L, Spiliopoulou, A, Franke, L, North, K E, Kraft, P, Morrison, A C, Esko, T & Wilson, J F 2018, ' Author Correction : GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk ', Nature Communications, vol. 9, no. 1, pp. 2536 . https://doi.org/10.1038/s41467-018-04857-7, Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018), Nature Communications
- Accession number :
- edsair.doi.dedup.....d45fae0d2af7b52d48d6cec58d26e29d
- Full Text :
- https://doi.org/10.1038/s41467-018-04857-7