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Polypseudorotaxane and polydopamine linkage-based hyaluronic acid hydrogel network with a single syringe injection for sustained drug delivery
- Source :
- Carbohydrate polymers. 266
- Publication Year :
- 2021
-
Abstract
- Polypseudorotaxane structure and polydopamine bond-based crosslinked hyaluronic acid (HA) hydrogels including donepezil-loaded microspheres were developed for subcutaneous injection. Both dopamine and polyethylene glycol (PEG) were covalently bonded to the HA polymer for catechol polymerization and inclusion complexation with alpha-cyclodextrin (α-CD), respectively. A PEG chain of HA-dopamine-PEG (HD-PEG) conjugate was threaded with α-CD to make a polypseudorotaxane structure and its pH was adjusted to 8.5 for dopamine polymerization. Poly(lactic-co-glycolic acid) (PLGA)/donepezil microsphere (PDM) was embedded into the HD-PEG network for its sustained release. The HD-PEG/α-CD/PDM 8.5 hydrogel system exhibited an immediate gelation pattern, injectability through single syringe, self-healing ability, and shear-thinning behavior. Donepezil was released from the HD-PEG/α-CD/PDM 8.5 hydrogel in a sustained pattern. Following subcutaneous injection, the weight of excised HD-PEG/α-CD/PDM 8.5 hydrogel was higher than the other groups on day 14. These findings support the clinical feasibility of the HD-PEG/α-CD/PDM 8.5 hydrogel for subcutaneous injection.
- Subjects :
- Male
Indoles
Polymers and Plastics
Rotaxanes
Polymers
macromolecular substances
02 engineering and technology
Polyethylene glycol
Biodegradable Plastics
Poloxamer
Viscoelastic Substances
010402 general chemistry
01 natural sciences
chemistry.chemical_compound
Subcutaneous injection
PEG ratio
Hyaluronic acid
Materials Chemistry
Animals
Donepezil
Hyaluronic Acid
Cyclodextrins
Drug Carriers
Mice, Inbred ICR
Organic Chemistry
technology, industry, and agriculture
Hydrogels
021001 nanoscience & nanotechnology
Microspheres
0104 chemical sciences
PLGA
Drug Liberation
chemistry
Polymerization
Self-healing hydrogels
Drug delivery
0210 nano-technology
Nuclear chemistry
Subjects
Details
- ISSN :
- 18791344
- Volume :
- 266
- Database :
- OpenAIRE
- Journal :
- Carbohydrate polymers
- Accession number :
- edsair.doi.dedup.....d44f9f2e58e0564c45e912dc533ec5ab