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Comparison of the antioxidant status in tracheal and bronchoalveolar epithelial lining fluids in recurrent airway obstruction
- Source :
- Equine veterinary journal. 38(5)
- Publication Year :
- 2006
-
Abstract
- Summary Reasons for performing study: Following a period of airway inflammation the clearance of inflammatory cells along the mucociliary escalator may impose a considerable oxidant load on the trachea. Objectives: To determine the degree of oxidative stress in tracheal epithelial lining fluid (ELF) in comparison to that present in peripheral airways after an acute exposure to organic dust. Methods: Tracheal wash fluid and bronchoalveolar lavage fluid (BALF) were collected for cytology and antioxidant analyses from 6 recurrent airway obstruction (RAO)-affected horses and 6 healthy control horses before and after stabling on straw bedding for 24 h. Results: In RAO-affected horses, organic dust exposure resulted in a significant decrease in ascorbic acid concentration in tracheal ELF (P < 0.0001), which was greater than the decrease in bronchoalveolar ELF (P = 0.0003). The percentage decrease in tracheal ELF ascorbic acid correlated with the percentage decrease in bronchoalveolar ELF ascorbic acid (r = 0.76; P = 0.004) following exposure. Conclusions: Acute organic dust exposure results in significant antioxidant depletion in the trachea, which may reflect inflammation and oxidative processes in peripheral airways. Potential relevance: Further work is required to evaluate the role of ascorbic acid depletion in the pathogenesis of RAO.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Antioxidant
medicine.medical_treatment
Inflammation
Ascorbic Acid
medicine.disease_cause
Antioxidants
Epithelium
Pathogenesis
Recurrence
medicine
Animals
Horses
Lung Diseases, Obstructive
Recurrent airway obstruction
medicine.diagnostic_test
business.industry
Dust
General Medicine
respiratory system
medicine.disease
Ascorbic acid
respiratory tract diseases
Trachea
Oxidative Stress
Bronchoalveolar lavage
Respiratory epithelium
Female
Horse Diseases
medicine.symptom
business
Bronchoalveolar Lavage Fluid
Oxidation-Reduction
Oxidative stress
Subjects
Details
- ISSN :
- 04251644
- Volume :
- 38
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Equine veterinary journal
- Accession number :
- edsair.doi.dedup.....d448360de1f6aa2d680c52a3fe3528d8