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Aliphatic amino diacid Asu functions as an effective mimic of Tyr(SO3H) in sulfakinins for myotropic and food intake-inhibition activity in insects
- Source :
- Peptides. 26:115-120
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- The aliphatic amino diacid alpha-aminosuberic acid can function as an effective, stable mimic of the hydrolysis-susceptible Tyr(SO3H) group in sulfakinin neuropeptide analogs for both hindgut contractile activity in cockroach and food intake-inhibition activity in the desert locust. In the analog, the acidic sulfate group is replaced with an acidic carboxyl group. The degree of activity of sulfakinin analogs is correlated with the carboxyl/alpha-carbon distance in the cockroach hindgut contractile assay. The results represent an important step in the design and synthesis of biostable, sulfakinin analogs that could potentially suppress the feeding behavior of destructive insect pests of agricultural importance.
- Subjects :
- Models, Molecular
animal structures
Physiology
media_common.quotation_subject
Neuropeptide
Cockroaches
Insect
Biochemistry
Eating
Cellular and Molecular Neuroscience
Endocrinology
biology.animal
Animals
Dicarboxylic Acids
Caprylates
Tyrosine
Cholecystokinin
media_common
Cockroach
biology
Hindgut
biology.organism_classification
Gastrointestinal Tract
Insect Hormones
Locust
Subjects
Details
- ISSN :
- 01969781
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Peptides
- Accession number :
- edsair.doi.dedup.....d43ea2eed02478747679d2a7ff4bd45b