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Ten years of chest MRI for patients with cystic fibrosis
- Source :
- Der Radiologe. 59:10-20
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Despite recent advances in our knowledge about the pathophysiology and treatment of cystic fibrosis (CF), pulmonary involvement remains the most important determinant of morbidity and mortality in patients with CF. Since lung function testing may not be sensitive enough for subclinical disease progression, and because young children may have normal spirometry results over a longer period of time, imaging today plays an increasingly important role in clinical routine and research for the monitoring of CF lung disease. In this regard, chest magnetic resonance imaging (MRI) could serve as a radiation-free modality for structural and functional lung imaging. Our research agenda encompassed the entire process of development, implementation, and validation of appropriate chest MRI protocols for use with infant and adult CF patients alike. After establishing a general MRI protocol for state-of-the-art clinical 1.5-T scanners based on the available sequence technology, a semiquantitative scoring system was developed followed by cross-validation of the method against the established modalities of computed tomography, radiography, and lung function testing. Cross-sectional studies were then set up to determine the sensitivity of the method for the interindividual variation of the disease and for changes in disease severity after treatment. Finally, the MRI protocol was implemented at multiple sites to be validated in a multicenter setting. After more than a decade, lung MRI has become a valuable tool for monitoring CF in clinical routine application and as an endpoint for clinical studies.
- Subjects :
- Adult
Male
medicine.medical_specialty
Cystic Fibrosis
Radiography
Cystic fibrosis
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Child
Lung
Cardiac imaging
Neuroradiology
medicine.diagnostic_test
business.industry
Infant
Magnetic resonance imaging
Interventional radiology
medicine.disease
Magnetic Resonance Imaging
Functional imaging
Cross-Sectional Studies
medicine.anatomical_structure
Child, Preschool
030220 oncology & carcinogenesis
Female
Radiology
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 14322102 and 0033832X
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Der Radiologe
- Accession number :
- edsair.doi.dedup.....d4347d8b66d7da19483c3f72287d1df0