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Vector competence of Aedes aegypti from Havana, Cuba, for dengue virus type 1, chikungunya, and Zika viruses
- Source :
- PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008941 (2020), PLoS Neglected Tropical Diseases
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- Background Like many countries from the Americas, Cuba is threatened by Aedes aegypti-associated arboviruses such as dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) viruses. Curiously, when CHIKV was actively circulating in the region in 2013–2014, no autochthonous transmission of this virus was detected in Havana, Cuba, despite the importation of chikungunya cases into this city. To investigate if the transmission ability of local mosquito populations could explain this epidemiological scenario, we evaluated for the first time the vector competence of two Ae. aegypti populations (Pasteur and Párraga) collected from Havana for dengue virus type 1 (DENV-1), CHIKV, and ZIKV. Methodology/Principal findings Mosquito populations were fed separately using blood containing ZIKV, DENV-1, or CHIKV. Infection, dissemination, and transmission rates, were estimated at 3 (exclusively for CHIKV), 7, and 14 days post exposure (dpe) for each Ae. aegypti population-virus combination. Both mosquito populations were susceptible to DENV-1 and ZIKV, with viral infection and dissemination rates ranging from 24–97% and 6–67% respectively. In addition, CHIKV disseminated in both populations and was subsequently transmitted. Transmission rates were low (<br />Author summary Dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) viruses are mainly transmitted by Aedes aegypti mosquitoes and together caused near 10 million human cases in the last decade in the Americas. The diseases caused by these viruses share symptoms ranging from mild clinical manifestations to severe complications, including fatal outcomes. Cuba has not been exempted from these viruses and is frequently subjected to dengue and more recently by diseases caused by ZIKV infection. Surprisingly, despite multiple CHIKV outbreaks recorded in neighboring countries, local circulation has not been reported in Havana. Although Ae. aegypti has been implicated as the major DENV and ZIKV vector because of its wide distribution on the island, neither field nor experimental approaches have been used to demonstrate the ability of Cuban Ae. aegypti populations to transmit DENVs, ZIKV, and CHIKV. In this laboratory study, we demonstrated that two Ae. aegypti populations from Havana could become infected with and transmit these viruses, albeit at low rates. Our paper suggests that the absence of CHIKV circulation in Havana was not related to refractoriness of Ae. aegypti populations to this virus; therefore, vector control remains being essential in preventing future arboviruses outbreaks.
- Subjects :
- RNA viruses
Viral Diseases
Physiology
viruses
RC955-962
Disease Vectors
Dengue virus
Pathology and Laboratory Medicine
medicine.disease_cause
Mosquitoes
Geographical locations
Disease Outbreaks
Zika virus
Dengue fever
Dengue
Medical Conditions
0302 clinical medicine
Aedes
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Chikungunya
0303 health sciences
education.field_of_study
Chikungunya Virus
Zika Virus Infection
Cuba
Eukaryota
virus diseases
Body Fluids
3. Good health
Insects
Infectious Diseases
Medical Microbiology
Viral Pathogens
Viruses
Female
Pathogens
Anatomy
Public aspects of medicine
RA1-1270
Research Article
Neglected Tropical Diseases
Arthropoda
Alphaviruses
030231 tropical medicine
Population
Mosquito Vectors
Aedes aegypti
Aedes Aegypti
Biology
Microbiology
Arbovirus
Togaviruses
03 medical and health sciences
medicine
Animals
Humans
Saliva
education
Microbial Pathogens
030304 developmental biology
Caribbean
Biology and life sciences
Flaviviruses
Organisms
Public Health, Environmental and Occupational Health
Chikungunya Infection
Outbreak
Zika Virus
Dengue Virus
Tropical Diseases
biology.organism_classification
medicine.disease
Invertebrates
Virology
Insect Vectors
Species Interactions
North America
Chikungunya Fever
People and places
Zoology
Entomology
Subjects
Details
- Language :
- English
- ISSN :
- 19352735 and 19352727
- Volume :
- 14
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....d42c07231a27138fd6300e8dc158e145