Back to Search
Start Over
Peripheral blood CD34+ cell monitoring after cyclophosphamide and granulocyte-colony-stimulating factor: an algorithm for the pre-emptive use of plerixafor
- Source :
- Leukemia & Lymphoma. 55:331-336
- Publication Year :
- 2013
- Publisher :
- Informa UK Limited, 2013.
-
Abstract
- Plerixafor "on demand" after chemotherapy plus granulocyte-colony-stimulating factor (G-CSF) is efficient in peripheral stem cell mobilization, but the timing of administration and criteria for patient selection are under investigation. To devise an algorithm for the "on demand" use of plerixafor at the first mobilization attempt, we analyzed the kinetics of hematopoietic recovery and peripheral blood CD34+ cells in 107 patients treated with high-dose cyclophosphamide plus G-CSF. Fifty-one patients with myeloma were treated with cyclophosphamide 3-4 g/m(2) on day 0 followed by G-CSF 10 μg/kg from day + 6, and 56 patients with lymphoma received cyclophosphamide 6-7 g/m(2) followed by G-CSF 5 μg/kg from day + 1. Peripheral blood CD34+ cell monitoring was started on day + 8 in patients with myeloma and day + 10 in patients with lymphoma. The outcome of interest was a collection of ≤ 2 × 10(6) CD34+/kg. By a multivariate logistic regression model, CD34+ cell count10/μL at leukocyte recovery (1000/μL) or leukocyte count1000/μL after day + 12 in myeloma and day + 14 in lymphoma predicted the failure of mobilization by 2.7 and 2.8 times (p = 0.001 and p = 0.02) with a sensitivity of 89% and specificity of 88%, respectively. Plerixafor "on demand" may be considered in patients with myeloma and lymphoma with delayed hematopoietic recovery and10/μL CD34+ cells, as a first-line mobilization strategy.
- Subjects :
- Adult
Male
Benzylamines
Cancer Research
Time Factors
Cyclophosphamide
medicine.medical_treatment
CD34
Antigens, CD34
Cyclams
Transplantation, Autologous
Leukocyte Count
Young Adult
Heterocyclic Compounds
Antineoplastic Combined Chemotherapy Protocols
Granulocyte Colony-Stimulating Factor
medicine
Humans
Antineoplastic Agents, Alkylating
Aged
Chemotherapy
business.industry
Lymphoma, Non-Hodgkin
Plerixafor
Hematopoietic Stem Cell Transplantation
Hematology
Middle Aged
Hematopoietic Stem Cells
medicine.disease
Hematopoietic Stem Cell Mobilization
Lymphoma
Granulocyte colony-stimulating factor
Transplantation
Haematopoiesis
Logistic Models
Oncology
Multivariate Analysis
Leukocytes, Mononuclear
Female
Multiple Myeloma
business
Algorithm
Algorithms
medicine.drug
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....d429bb7ad9dd025b83ec0780b04a3e42