Back to Search
Start Over
Contributions to osteoclast biology from Japan
- Source :
- Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
- Publication Year :
- 2008
- Publisher :
- Japan Academy, 2008.
-
Abstract
- Bone is a dynamic tissue, in which bone formation by osteoblasts and bone resorption by osteoclasts continue throughout life. In 1998, we molecularly cloned osteoclast differentiation factor (ODF), a long-thought factor responsible for osteoclast formation. This review article describes how Japanese scientists contributed to osteoclast biology before and after the discovery of ODF. This review article is based on the Louis V. Avioli Memorial Lecture of the American Society for Bone and Mineral Research (ASBMR) held in Honolulu in September, 2007.
- Subjects :
- musculoskeletal diseases
Osteoclast Differentiation Factor
medicine.medical_specialty
OCIF/OPG
Osteoclasts
General Physics and Astronomy
Review
Biology
Bone resorption
Cell Fusion
ODF/RANKL
Japan
osteoclast formation and activation
Osteoclast
Internal medicine
medicine
Animals
Humans
Bone formation
Bone Resorption
Cloning, Molecular
DC-STAMP
NFATc1/NFAT2
Research
Proteins
General Medicine
M-CSF
Hormones
medicine.anatomical_structure
Endocrinology
Cancer research
General Agricultural and Biological Sciences
Subjects
Details
- ISSN :
- 13492896 and 03862208
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Proceedings of the Japan Academy, Series B
- Accession number :
- edsair.doi.dedup.....d426959305743a8dd9d850349f8a0dde