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The vitamin D metabolites 25(OH)D and 1,25(OH)2D are not related to either glucose metabolism or insulin action in obese women
- Source :
- ter Horst, K W, Versteeg, R I, Gilijamse, P W, Ackermans, M T, Heijboer, A C, Romijn, J A, la Fleur, S E, Trinko, R, DiLeone, R J & Serlie, M J 2016, ' The vitamin D metabolites 25(OH)D and 1,25(OH) 2 D are not related to either glucose metabolism or insulin action in obese women ', Diabetes and Metabolism, vol. 42, no. 6, pp. 416-423 . https://doi.org/10.1016/j.diabet.2016.04.011, Diabetes and Metabolism, 42(6), 416-423. Elsevier Masson, Diabetes & metabolism, 42(6), 416-423. Elsevier Masson
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Aim: Vitamin D deficiency has been proposed to be involved in obesity-induced metabolic disease. However, data on the relationship between 25-hydroxycholecalciferol (25(OH)D) and insulin resistance have been inconsistent, and few studies have investigated the active vitamin D metabolite, 1,25-dihydroxycholecalciferol (1,25(OH)2D). This study aimed to determine the relationship between circulating levels of both 25(OH)D and 1,25(OH)2D and direct measures of glucose metabolism and insulin action in obese women. Methods: Serum levels of 25(OH)D and 1,25(OH)2D, and glucose metabolism and tissue-specific insulin action, as assessed in the basal state and during a two-step euglycaemic-hyperinsulinaemic clamp study with [6,6-2H2]glucose infusion, were measured in 37 morbidly obese women (age: 43±10 years; body mass index: 44±6kg/m2). Results: Sixteen subjects had circulating 25(OH)D levels2D, was negatively correlated with both body mass index (r =-0.42, P =0.01) and total body fat (r =-0.46, P 2D levels were related to any measured metabolic parameters, including fasting glucose, fasting insulin, basal endogenous glucose production, and hepatic, adipose-tissue and skeletal muscle insulin sensitivity. Conclusion: Obesity was associated with lower levels of circulating 25(OH)D, but not with the hormonally active metabolite 1,25(OH)2D. Neither 25(OH)D nor 1,25(OH)2D were related to glucose metabolism and tissue-specific insulin sensitivity in obese women, suggesting that vitamin D does not play a major role in obesity-related insulin resistance.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Calcitriol
Endocrinology, Diabetes and Metabolism
Metabolite
medicine.medical_treatment
030209 endocrinology & metabolism
Biology
Carbohydrate metabolism
vitamin D deficiency
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Insulin resistance
Internal medicine
Internal Medicine
medicine
Vitamin D and neurology
Insulin
General Medicine
medicine.disease
030104 developmental biology
chemistry
Basal (medicine)
medicine.drug
Subjects
Details
- ISSN :
- 12623636
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolism
- Accession number :
- edsair.doi.dedup.....d41cc1d2ea94b3ae8379833f0be3c783
- Full Text :
- https://doi.org/10.1016/j.diabet.2016.04.011