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The vitamin D metabolites 25(OH)D and 1,25(OH)2D are not related to either glucose metabolism or insulin action in obese women

Authors :
Richard Trinko
Johannes A. Romijn
Pim W. Gilijamse
Mariƫtte T. Ackermans
S.E. la Fleur
K.W. ter Horst
Ruth I. Versteeg
Annemieke C. Heijboer
Ralph J. DiLeone
Mireille J. Serlie
Clinical chemistry
MOVE Research Institute
Anesthesiology
Other departments
Endocrinology
Laboratory for Endocrinology
General Internal Medicine
Source :
ter Horst, K W, Versteeg, R I, Gilijamse, P W, Ackermans, M T, Heijboer, A C, Romijn, J A, la Fleur, S E, Trinko, R, DiLeone, R J & Serlie, M J 2016, ' The vitamin D metabolites 25(OH)D and 1,25(OH) 2 D are not related to either glucose metabolism or insulin action in obese women ', Diabetes and Metabolism, vol. 42, no. 6, pp. 416-423 . https://doi.org/10.1016/j.diabet.2016.04.011, Diabetes and Metabolism, 42(6), 416-423. Elsevier Masson, Diabetes & metabolism, 42(6), 416-423. Elsevier Masson
Publication Year :
2016
Publisher :
Elsevier BV, 2016.

Abstract

Aim: Vitamin D deficiency has been proposed to be involved in obesity-induced metabolic disease. However, data on the relationship between 25-hydroxycholecalciferol (25(OH)D) and insulin resistance have been inconsistent, and few studies have investigated the active vitamin D metabolite, 1,25-dihydroxycholecalciferol (1,25(OH)2D). This study aimed to determine the relationship between circulating levels of both 25(OH)D and 1,25(OH)2D and direct measures of glucose metabolism and insulin action in obese women. Methods: Serum levels of 25(OH)D and 1,25(OH)2D, and glucose metabolism and tissue-specific insulin action, as assessed in the basal state and during a two-step euglycaemic-hyperinsulinaemic clamp study with [6,6-2H2]glucose infusion, were measured in 37 morbidly obese women (age: 43±10 years; body mass index: 44±6kg/m2). Results: Sixteen subjects had circulating 25(OH)D levels2D, was negatively correlated with both body mass index (r =-0.42, P =0.01) and total body fat (r =-0.46, P 2D levels were related to any measured metabolic parameters, including fasting glucose, fasting insulin, basal endogenous glucose production, and hepatic, adipose-tissue and skeletal muscle insulin sensitivity. Conclusion: Obesity was associated with lower levels of circulating 25(OH)D, but not with the hormonally active metabolite 1,25(OH)2D. Neither 25(OH)D nor 1,25(OH)2D were related to glucose metabolism and tissue-specific insulin sensitivity in obese women, suggesting that vitamin D does not play a major role in obesity-related insulin resistance.

Details

ISSN :
12623636
Volume :
42
Database :
OpenAIRE
Journal :
Diabetes & Metabolism
Accession number :
edsair.doi.dedup.....d41cc1d2ea94b3ae8379833f0be3c783
Full Text :
https://doi.org/10.1016/j.diabet.2016.04.011