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Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders
- Source :
- British Journal of Clinical Pharmacology
- Publication Year :
- 2016
-
Abstract
- The mammalian target of rapamycin (mTOR) pathway is an highly conserved signal transduction axis involved in many cellular processes, such as cell growth, survival, transcription, translation, apoptosis, metabolism, motility and autophagy. Recently, this signalling pathway has come to the attention of the scientific community owing to the unexpected finding that inhibition of mTOR by rapamycin, an antibiotic with immunosuppressant and chemotherapeutic properties, extends lifespan in diverse animal models. Moreover, rapamycin has been reported to rescue the cellular phenotype in a progeroid syndrome [Hutchinson–Gilford Progeria syndrome (HGPS)] that recapitulates most of the traits of physiological ageing. The promising perspectives raised by these results warrant a better understanding of mTOR signalling and the potential applications of mTOR inhibitors to counteract ageing‐associated diseases and increase longevity. This review is focused on these issues.
- Subjects :
- 0301 basic medicine
mTOR inhibitors
Aging
mTOR inhibitor
Protein Kinase Inhibitor
Biology
Models, Biological
03 medical and health sciences
Progeria
medicine
Animals
Humans
Pharmacology (medical)
progeria‐related diseases
Protein Kinase Inhibitors
PI3K/AKT/mTOR pathway
lamin A
Pharmacology
integumentary system
Cell growth
rapamycin
Animal
progeria-related disease
TOR Serine-Threonine Kinases
Autophagy
Review‐themed Issue
Hutchinson–Gilford Progeria syndrome (HGPS)
medicine.disease
Hedgehog signaling pathway
Cell biology
030104 developmental biology
ageing
Signal transduction
Lamin
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- British Journal of Clinical Pharmacology
- Accession number :
- edsair.doi.dedup.....d41b143b8b5ee3cdd9e07f5373ead0cc