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Diverging trajectory patterns of systemic versus vascular inflammation over age in healthy Caucasians and African-Americans
- Source :
- Atherosclerosis. 239:509-515
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Age and inflammation are risk factors for cardiovascular disease but the impact of inflammation on cardiovascular risk across the lifespan is not understood. We investigated whether an inflammatory burden is modulated by age in healthy subjects.Caucasian and African-American families were recruited from the general population (age range: 6-74 years, n = 267). Systemic inflammation was assessed by C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen, haptoglobin and α-acid glycoprotein, and vascular inflammation was assessed by pentraxin-3 (PTX-3), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM). To collectively assess systemic or vascular factors across the age spectrum, a composite z-score for each marker category was calculated.There was a contrasting pattern in systemic versus vascular inflammatory burden over age with an increase in systemic but a decrease in vascular markers in both ethnic groups. The results remained unchanged after adjustments for the covariates and covariance. When looking at individual markers to examine which markers are most contributing factors to the composite scores, CRP and SAA were significantly and positively associated with age, while PTX-3 and sVCAM were significantly and negatively associated with age in both ethnic groups.The composite z-score for systemic inflammation increased with age, while the composite z-score for vascular inflammation declined with age, irrespective of ethnicity. The findings illustrate a regulatory relationship between age and inflammation, and suggest that a perceived elevation of vascular markers among the very young may be an indication of physiological changes rather than reflecting a disease process.
- Subjects :
- Adult
Male
Vasculitis
Time Factors
Adolescent
Composite score
Inflammation
Disease
California
White People
Article
Age Distribution
Risk Factors
medicine
Humans
Child
Vascular inflammation
business.industry
Age Factors
Healthy subjects
Health Status Disparities
Middle Aged
Prognosis
Inflammatory biomarkers
Healthy Volunteers
Black or African American
Cross-Sectional Studies
Immunology
Female
Inflammation Mediators
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 00219150
- Volume :
- 239
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....d40f327fb89165dd051908aaa966f6e5