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Association of a functional BDNF polymorphism and anxiety-related personality traits
- Source :
- Psychopharmacology. 180:95-99
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- Converging lines of evidence point to brain-derived neurotrophic factor (BDNF) as a factor in the pathophysiology of depression. Recently, it was shown that the Val allele of the BDNF Val66Met substitution polymorphism showed a significant association with higher mean neuroticism scores of the NEO-Five Factor Inventory (NEO-FFI) in healthy subjects, and previous studies suggested the Val allele to be increased in bipolar disorder families. The association to anxiety-related traits has not been investigated so far.We tested a total of 343 unrelated subjects of German descent (171 male, 172 female, age: 39.0+/-14.6 years) who were carefully screened for psychiatric health. The self-ratable State-Trait Anxiety Inventory (STAI), which allows anxiety to be quantified as a comparatively stable personality trait, and the NEO-Five Factor Inventory (NEO-FFI) was applied.In the trait-related anxiety score, a significant (F=3.2, df=2, p0.042) effect of the genotype was observed with higher levels of trait anxiety in Val/Val (35.0+/-7.4) compared to Val/Met (33.4+/-6.5) and Met/Met (32.0+/-4.6) genotypes. The NEO neuroticism scores were also higher in Val/Val (29.5+/-7.0) than in Val/Met (28.4+/-6.5) or Met/Met (26.8+/-5.8) genotype, but not at a significant rate.Our findings support the hypothesis that anxiety- and depression-related personality traits are associated with the BDNF polymorphism although the explained variance is low.
- Subjects :
- Adult
Male
medicine.medical_specialty
Genotype
Psychometrics
Polymorphism, Single Nucleotide
White People
Polymorphism (computer science)
Internal medicine
medicine
Humans
Bipolar disorder
Allele
Big Five personality traits
Psychiatry
Psychiatric Status Rating Scales
Pharmacology
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor
medicine.disease
Anxiety Disorders
Neuroticism
Endocrinology
Anxiety
Female
medicine.symptom
Psychology
Personality
Subjects
Details
- ISSN :
- 14322072 and 00333158
- Volume :
- 180
- Database :
- OpenAIRE
- Journal :
- Psychopharmacology
- Accession number :
- edsair.doi.dedup.....d40a107d0a46f576ef102b94510b27c6