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Inhibition by thyrocalcitonin (calcitonin) of the cyclic AMP- mediated stimulation of thymocyte proliferation by epinephrine
- Publication Year :
- 1971
-
Abstract
- Epinephrine stimulates the proliferation of rat thymic lymphocytes maintained in vitro by a cyclic AMP-mediated process. The mitogenic action of epinephrine is completely inhibited by low concentrations (6.0 to 8.0 mU per ml) of a highly purified sample of porcine thyrocalcitonin (calcitonin). In view of the fact that the same low levels of thyrocalcitonin are known to inhibit the cyclic AMP-mediated mitogenic action of vasopressin and the similar physiologically important mitogenic action of parathyroid hormone, it is proposed that thyrocalcitonin (calcitonin) may be general regulator of cyclic AMP-controlled cell proliferation in vivo. (Author)
- Subjects :
- Calcitonin
Male
Vasopressin
medicine.medical_specialty
Epinephrine
Swine
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Parathyroid hormone
Stimulation
Thymus Gland
Biology
Biochemistry
Endocrinology
In vivo
Internal medicine
medicine
Cyclic AMP
Animals
Lymphocytes
Cells, Cultured
Cell growth
Biochemistry (medical)
General Medicine
Rats
Kinetics
Cardiovascular agent
Drug Antagonism
Cell Division
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d407045e89885c4ee0c126b5846ffeb4