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Increased incidence of axonal Guillain‐Barré syndrome in La Spezia area of Italy: A 13‐year follow‐up study
- Source :
- Journal of the Peripheral Nervous System. 24:80-86
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Guillain-Barre syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy with a worldwide incidence of 0.81-1.89 per 100 000 person-years. In Europe and North America only 5% of patients with GBS have axonal subtypes, which in South America and Asia account for 30%-47% of cases. The aim of our study is to assess the annual incidence and clinical features of GBS in La Spezia area in Italy. A retrospective (from 1 January 2003 to 31 December 2011) followed by a prospective (from 1 January 2012 to 31 December 2015) analysis was carried out on patients admitted to La Spezia hospital who fulfilled the GBS diagnostic criteria. A total of 86 patients (58 men), mean age of 62.7 years (range 21-90), were included. The mean annual incidence rate was 3/100 000 (range: 0.9/100 000-5.37/100 000) significantly higher than the European incidence (P < 0.001). Forty-seven percent were classified as acute inflammatory demyelinating polyradiculoneuropathy (AIDP), 35% as acute motor and motor-sensory axonal neuropathy (AMAN-AMSAN), 13% as variant forms, and 5% were not defined. AIDP was most common in "Golfo dei Poeti" (50%) and "Val di Magra" (63.2%), whereas AMAN/AMSAN prevailed in "Val di Vara" (63.6%) and "Riviera Spezzina" (62.5%) (P = 0.024). In La Spezia area GBS incidence (especially the AMAN subtype) is significantly higher than the incidence reported in Europe. AIDP predominates in the eastern area whereas AMAN/AMSAN in the western, with a significantly different incidence rate (P = 0.003). Prospective studies to assess possible predisposing environmental factors are needed.
- Subjects :
- Adult
Male
Axonal neuropathy
Pediatrics
medicine.medical_specialty
annual incidence
Guillain-Barre Syndrome
AIDP
Annual incidence
Young Adult
03 medical and health sciences
AMAN
0302 clinical medicine
Guillain-Barré syndrome
medicine
Humans
Prospective cohort study
Aged
Aged, 80 and over
Neuroscience (all)
Guillain-Barre syndrome
business.industry
Incidence
General Neuroscience
Incidence (epidemiology)
Follow up studies
Polyradiculoneuropathy
Mean age
Middle Aged
medicine.disease
Axons
Neurology (clinical)
Italy
030220 oncology & carcinogenesis
Female
business
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 15298027 and 10859489
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of the Peripheral Nervous System
- Accession number :
- edsair.doi.dedup.....d406df8e348de05104366d8e560d9593