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Triple-negative breast cancer on contrast-enhanced MRI and synthetic MRI: A comparison with non-triple-negative breast carcinoma
- Source :
- European journal of radiology. 142
- Publication Year :
- 2020
-
Abstract
- Purpose This study aimed to compare the characteristics of triple-negative breast cancer (TNBC) with non-TNBC on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and synthetic MRI. Method This retrospective study included 79 patients with histopathologically proven breast cancer (TNBC: 16, non-TNBC: 63) who underwent synthetic MRI. Using synthetic MR images, we obtained T1 and T2 relaxation times in breast lesions before (Pre-T1, Pre-T2, Pre-PD) and after (Gd-T1, Gd-T2, Gd-PD) contrast agent injection. Subsequently, we calculated the ΔT1 (Pre-T1 – Gd-T1), ΔT2 (Pre-T2 – Gd-T2), Pre-T1/T2, and Gd-T1/T2. We compared the aforementioned quantitative values, as well as several morphologic features between TNBCs and non-TNBCs that were identified on DCE-MRI. Results The multivariate analyses revealed that the Pre-T2 (P = 0.037) and the presence of rim enhancement (P-RIM) (P = 0.034) were significant and independent predictors of TNBC. The area under the receiver operating characteristics curve for all breast cancers was greater when a combination of Pre-T2 and P-RIM (Pre-T2+P-RIM; Method 3, AUC (area under the curve) = 0.858) was used to distinguish between TNBCs and non-TNBCs versus the use of either Pre-T2 alone (Method 1, AUC = 0.786) or P-RIM alone (Method 2, AUC = 0.747). Conclusions Pre-T2 obtained using synthetic MRI and P-RIM identified on DCE-MRI allowed the differentiation between TNBCs and non-TNBCs. However, these results are preliminary and need to be verified by further studies.
- Subjects :
- medicine.diagnostic_test
CONTRAST ENHANCED MRI
Receiver operating characteristic
business.industry
Area under the curve
Contrast Media
Magnetic resonance imaging
Retrospective cohort study
Breast Neoplasms
Triple Negative Breast Neoplasms
General Medicine
medicine.disease
Magnetic Resonance Imaging
Breast cancer
medicine
Humans
Radiology, Nuclear Medicine and imaging
Triple-Negative Breast Carcinoma
Female
Breast
Nuclear medicine
business
Triple-negative breast cancer
Retrospective Studies
Subjects
Details
- ISSN :
- 18727727
- Volume :
- 142
- Database :
- OpenAIRE
- Journal :
- European journal of radiology
- Accession number :
- edsair.doi.dedup.....d40383c560284b18dc7781605cbc7fd4