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Parkinson's Disease: Extracellular Nanomatrix‐Induced Self‐Organization of Neural Stem Cells into Miniature Substantia Nigra‐Like Structures with Therapeutic Effects on Parkinsonian Rats (Adv. Sci. 24/2019)

Authors :
Florence Hiu Ling Chan
Kaili Lin
Vellaisamy A. L. Roy
Qi Gao
Shiqing Zhang
King Wai Chiu Lai
Hongqi Zhang
Peng Sun
Wai Fung Lau
Zhifeng Huang
Ken Kin Lam Yung
Source :
Advanced Science
Publication Year :
2019
Publisher :
Wiley, 2019.

Abstract

In article number https://doi.org/10.1002/advs.201901822, King Wai Chiu Lai, Zhifeng Huang, Ken Kin Lam Yung, and co‐workers develop a biocompatible silica sculptured in nanozigzags by glancing angle deposition. The nanomatrix induces self‐organization of neural stem cells into miniature substantia nigra‐like brain structures, which could deliver early and progressive amelioration in Parkinsonian rats. These results provide significant insight into novel cell therapies for Parkinson's disease.

Details

ISSN :
21983844 and 20190182
Volume :
6
Database :
OpenAIRE
Journal :
Advanced Science
Accession number :
edsair.doi.dedup.....d3faf96923d030aadf6bec4f5b49f235