Back to Search
Start Over
Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey
- Source :
- PLoS ONE, PLoS ONE, Vol 8, Iss 12, p e83026 (2013)
- Publication Year :
- 2013
- Publisher :
- Public Library of Science, 2013.
-
Abstract
- BackgroundBone metastasis represents an increasing clinical problem in advanced renal cell carcinoma (RCC) as disease-related survival improves. There are few data on the natural history of bone disease in RCC.Patients and methodsData on clinicopathology, survival, skeletal-related events (SREs), and bone-directed therapies for 398 deceased RCC patients (286 male, 112 female) with evidence of bone metastasis were statistically analyzed.ResultsMedian time to bone metastasis was 25 months for patients without bone metastasis at diagnosis. Median time to diagnosis of bone metastasis by MSKCC risk was 24 months for good, 5 months for intermediate, and 0 months for poor risk. Median number of SREs/patient was one, and 71% of patients experienced at least one SRE. Median times to first, second, and third SRE were 2, 5, and 12 months, respectively. Median survival was 12 months after bone metastasis diagnosis and 10 months after first SRE. Among 181 patients who received zoledronic acid (ZOL), median time to first SRE was significantly prolonged versus control (n = 186) (3 months vs 1 month for control; PConclusionsRCC patients with bone metastasis are at continuous risk of SREs, and in this survey ZOL effectively reduced this risk.
- Subjects :
- Oncology
Male
Anatomy and Physiology
Bone disease
Epidemiology
Settore MED/06 - Oncologia Medica
medicine.medical_treatment
Metastasis
bone metastases
Renal cell carcinoma
Basic Cancer Research
Medicine
Musculoskeletal System
Multidisciplinary
Diphosphonates
renal cell carcinoma, bone metastasis, zoledronic acid
Bone metastasis
Kidney Neoplasms
Italy
Observational Studies
Disease Progression
Female
Cancer Epidemiology
medicine.drug
Research Article
medicine.medical_specialty
Clinical Research Design
Science
renal cancer
Bone Neoplasms
Internal medicine
Humans
Bone
Retrospective Studies
business.industry
Renal Cell Carcinoma
Cancer
Cancers and Neoplasms
Bone fracture
medicine.disease
Surgery
Radiation therapy
Genitourinary Tract Tumors
Zoledronic acid
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, PLoS ONE, Vol 8, Iss 12, p e83026 (2013)
- Accession number :
- edsair.doi.dedup.....d3f7374ca924135aadb32d1444fade1e