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Molecular optical imaging with radioactive probes
- Source :
- PLoS ONE, Vol 5, Iss 3, p e9470 (2010), PLoS ONE
- Publication Year :
- 2010
- Publisher :
- Public Library of Science (PLoS), 2010.
-
Abstract
- Background Optical imaging (OI) techniques such as bioluminescence and fluorescence imaging have been widely used to track diseases in a non-invasive manner within living subjects. These techniques generally require bioluminescent and fluorescent probes. Here we demonstrate the feasibility of using radioactive probes for in vivo molecular OI. Methodology/Principal Findings By taking the advantages of low energy window of light (1.2–3.1 eV, 400–1000 nm) resulting from radiation, radionuclides that emit charged particles such as β+ and β− can be successfully imaged with an OI instrument. In vivo optical images can be obtained for several radioactive probes including 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), Na18F, Na131I, 90YCl3 and a 90Y labeled peptide that specifically target tumors. Conclusions/Significance These studies demonstrate generalizability of radioactive OI technique. It provides a new molecular imaging strategy and will likely have significant impact on both small animal and clinical imaging.
- Subjects :
- Diagnostic Imaging
Fluorescence-lifetime imaging microscopy
Fluorine Radioisotopes
Optics and Photonics
Materials science
Radiology and Medical Imaging
Mice, Nude
lcsh:Medicine
Sodium Iodide
Radiation
030218 nuclear medicine & medical imaging
Iodine Radioisotopes
03 medical and health sciences
Mice
0302 clinical medicine
Nuclear magnetic resonance
Fluorodeoxyglucose F18
medicine
Medical imaging
Bioluminescence
Animals
Humans
Yttrium
Yttrium Radioisotopes
lcsh:Science
Tomography, Emission-Computed, Single-Photon
Multidisciplinary
medicine.diagnostic_test
business.industry
Phantoms, Imaging
lcsh:R
Fluorescence
3. Good health
Oncology
Positron emission tomography
030220 oncology & carcinogenesis
Positron-Emission Tomography
Sodium Fluoride
Radiology and Medical Imaging/PET and SPECT Imaging
lcsh:Q
Molecular imaging
Radiopharmaceuticals
Nuclear medicine
business
Tomography, X-Ray Computed
Preclinical imaging
Neoplasm Transplantation
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 5
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d3ea9dba4e6f93f8f3f2beeb6334030a