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IL-4/IL-13 remodeling pathway of COVID-19 lung injury
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- Background: The COVID-19 fatality rate is high when compared to the H1N1pdm09 (pandemic Influenza A virus H1N1 subtype) rate, and although both cause an aggravated inflammatory response, the differences in the mechanisms of both pandemic pneumonias need clarification.Objective: To analyze tissue expression of interleukins 4, 13, (IL-4, IL-13), transforming growth factor-beta (TGF-β), and the number of M2 macrophages (Sphingosine-1) in patients who died by COVID-19, comparing with cases of severe pneumopathy caused by H1N1pdm09, and a control group without lung injury.Methods: Six lung biopsy samples of patients who died of SARS-CoV-2 (COVID-19 group) were used and compared with ten lung samples of adults who died from a severe infection of H1N1pdm09 (H1N1 group) and eleven samples of patients who died from different causes without lung injury (CONTROL group). The expression of IL-4, IL-13, TGF-β, and M2 macrophages score (Sphingosine-1) were identified through immunohistochemistry (IHC).Results and conclusion: Significantly higher IL-4 tissue expression and Sphingosine-1 in M2 macrophages was observed in the COVID-19 group when compared to both the H1N1 and the CONTROL groups. Different mechanism of diffuse alveolar damage (DAD) in SARS-CoV-2 compared to H1N1pdm09 infections were observed. IL-4 expression and lung remodeling are phenomena observed in both SARS-COV-2 and H1N1pdm09. However, SARS-CoV-2 seems to promote lung damage through different mechanisms, such as the scarce participation Th1/Th17 response and the higher participation of the Th2. The understanding and management of the aggravated and ineffective immune response elicited by SARS-CoV-2 merits further clarification to improve treatments propose.
- Subjects :
- 0301 basic medicine
Male
Immunopathogenesis
Pneumonia, Viral
lcsh:Medicine
Lung biopsy
Lung injury
Article
03 medical and health sciences
Prognostic markers
0302 clinical medicine
Immune system
Sphingosine
Transforming Growth Factor beta
Medicine
Humans
Diffuse alveolar damage
lcsh:Science
Lung
Pandemics
Aged
Aged, 80 and over
Multidisciplinary
Interleukin-13
business.industry
Macrophages
lcsh:R
Interleukin
COVID-19
Middle Aged
respiratory tract diseases
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Immunology
Interleukin 13
Immunohistochemistry
lcsh:Q
Female
Interleukin-4
business
Coronavirus Infections
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....d3e855ed86c9e068e4ea8c10069bc87e