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mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family
- Source :
- Genes & Development. 16:388-398
- Publication Year :
- 2002
- Publisher :
- Cold Spring Harbor Laboratory, 2002.
-
Abstract
- The JAK/STAT signal transduction pathway controls numerous events inDrosophila melanogaster development. Receptors for the pathway have yet to be identified. Here we have identified a Drosophilagene that shows embryonic mutant phenotypes identical to those in the hopscotch (hop)/JAK kinase and marelle(mrl)/Stat92e mutations. We named this genemaster of marelle (mom). Genetic analyses placemom's function between upd (the ligand) andhop. We further show that cultured cells transfected with themom gene bind UPD and activate the HOP/STAT92E signal transduction pathway. mom encodes a protein distantly related to the mammalian cytokine receptor family. These data show thatmom functions as a receptor of the Drosophila JAK/STAT signal transduction pathway.
- Subjects :
- Molecular Sequence Data
Biology
Transfection
Genetics
Animals
Drosophila Proteins
Amino Acid Sequence
Cloning, Molecular
Receptors, Cytokine
Transcription factor
Cells, Cultured
In Situ Hybridization
Body Patterning
Glycoproteins
Janus Kinases
Janus kinase 1
Membrane Proteins
Exons
Janus Kinase 1
Protein-Tyrosine Kinases
biology.organism_classification
Introns
Cell biology
DNA-Binding Proteins
Trachea
STAT Transcription Factors
Drosophila melanogaster
ComputingMethodologies_PATTERNRECOGNITION
Trans-Activators
Insect Proteins
Female
Signal transduction
Cytokine receptor
Janus kinase
Drosophila Protein
Signal Transduction
Transcription Factors
Research Paper
Developmental Biology
Subjects
Details
- ISSN :
- 15495477 and 08909369
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Genes & Development
- Accession number :
- edsair.doi.dedup.....d3e7f3ca77e6f6a25392557190eb4c4a