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Role of adrenergic neuronal activity in the yawning induced by tacrine and NIK-247 in rats
- Source :
- Pharmacology Biochemistry and Behavior. 43:985-991
- Publication Year :
- 1992
- Publisher :
- Elsevier BV, 1992.
-
Abstract
- The present experiments were performed to investigate the potential role of central adrenergic neurons in regulating occurrence of yawning in rats. Intraperitoneal injection of tacrine (THA) or 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta(b)-quinoline monohydrate HCl (NIK-247), cholinesterase inhibitors, induced yawning, which was markedly increased by pretreatment with the beta-adrenoceptor antagonist, pindolol. The yawning evoked by tacrine or NIK-247 given alone or in combination with pindolol was inhibited by pretreatment with scopolamine but not by mecamylamine or spiperone. Treatment with tacrine or NIK-247 increased acetylcholine content of the striatum, but this effect was not enhanced by pindolol, which per se did not affect basal acetylcholine content. Moreover, pretreatment with the central adrenaline synthesis inhibitors, (+-)-2,3-dichloro-alpha-methylbenzylamine HCl (LY-78335) and 2-cyclooctyl-2-hydroxyethylamine HCl (UK-1187A), increased tacrine-induced yawning. Subcutaneous injection of talipexole (B-HT 920), a dopamine D2 receptor agonist, evoked yawning, which was also increased by pindolol, LY-78335, and UK-1187A. These receptors antagonists and synthesis inhibitors per se did not cause yawning responses. The results suggest that the beta-adrenoceptor blockade and the inhibition of adrenaline synthesis facilitate the occurrence of yawning induced by cholinergic and dopaminergic agonists, and thus the central adrenergic neuronal systems may be implicated in the regulation of yawning responses.
- Subjects :
- Male
Agonist
medicine.medical_specialty
Sympathetic Nervous System
medicine.drug_class
Adrenergic beta-Antagonists
Dopamine Agents
Clinical Biochemistry
Adrenergic
Receptors, Cell Surface
Pharmacology
Toxicology
Biochemistry
Behavioral Neuroscience
Internal medicine
Receptors, Adrenergic, beta
Mecamylamine
medicine
Animals
Rats, Wistar
Pindolol
Chromatography, High Pressure Liquid
Biological Psychiatry
Brain Chemistry
Neurons
Psychotropic Drugs
Behavior, Animal
Dose-Response Relationship, Drug
Chemistry
Azepines
Acetylcholine
Corpus Striatum
Talipexole
Rats
Endocrinology
Tacrine
Aminoquinolines
Cholinergic
Yawning
Cholinesterase Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 00913057
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Pharmacology Biochemistry and Behavior
- Accession number :
- edsair.doi.dedup.....d3dfa1c508c81b9efeabff9204212d4b