Back to Search
Start Over
Allelic variation of human serotonin transporter gene expression
- Source :
- ResearcherID
-
Abstract
- Mood, emotion, cognition, and motor functions as well as circadian and neuroendocrine rhythms, including food intake, sleep, and reproductive activity, are modulated by the midbrain raphe serotonin (5-HT) system. By directing the magnitude and duration of postsynaptic responses, carrier-facilitated 5-HT transport into and release from the presynaptic neuron are essential for the fine tuning of serotonergic neurotransmission. Interest in the mechanism of environmental factor-, disease-, and therapy-induced modification of 5-HT transporter (5-HTT) function and its impact on early brain development, event-related synaptic plasticity, and neurodegeneration is widespread and intensifying. We have recently characterized the human and murine 5-HTT genes and performed functional analyses of their 5'-flanking regulatory regions. A tandemly repeated sequence associated with the transcriptional apparatus of the human 5-HTT gene displays a complex secondary structure, represses promoter activity in nonserotonergic neuronal cells, and contains positive regulatory components. We now report a novel polymorphism of this repetitive element and provide evidence for allele-dependent differential 5-HTT promoter activity. Allelic variation in 5-HTT-related functions may play a role in the expression and modulation of complex traits and behavior.
- Subjects :
- Serotonin
Transcription, Genetic
Molecular Sequence Data
Nerve Tissue Proteins
Neurotransmission
Serotonergic
Biochemistry
Polymerase Chain Reaction
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Humans
Neurotransmitter
Serotonin transporter
Alleles
Repetitive Sequences, Nucleic Acid
Genetics
Serotonin Plasma Membrane Transport Proteins
Membrane Glycoproteins
Polymorphism, Genetic
biology
Base Sequence
Membrane Transport Proteins
chemistry
Gene Expression Regulation
Regulatory sequence
5-HTTLPR
Synaptic plasticity
biology.protein
Carrier Proteins
Neuroscience
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- ResearcherID
- Accession number :
- edsair.doi.dedup.....d3de051ee61cf754884b6bff66d6d7f9