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A Therapeutic Effect of Ulinastatin on Endotoxin-Induced Shock in Dogs. Comparison with Methylprednisolone
- Source :
- Journal of Veterinary Medical Science. 56:645-649
- Publication Year :
- 1994
- Publisher :
- Japanese Society of Veterinary Science, 1994.
-
Abstract
- The therapeutic effect of ulinastatin (25,000 U/kg, i.v.) on endotoxin-induced shock was compared with that of methylprednisolone (30 mg/kg, i.v.) in 17 anesthetized dogs. Both of these drugs had almost the same tendency to improve the hemodynamics, arachidonate cascade metabolites and pulmonary surface activity. There was little difference between the effectiveness of ulinastatin and that of methylprednisolone. It was newly confirmed that the release of 6-keto-PGF1 alpha, thromboxane B2 and leukotriene B4, arachidonate cascade metabolites and chemical mediators associated with endotoxin-induced shock, were significantly (p < 0.01 and p < 0.05) decreased by ulinastatin in the same way as methylprednisolone. These results suggest that ulinastatin is as useful as methylprednisolone for the treatment of endotoxin-induced shock.
- Subjects :
- Leukotriene B4
Alpha (ethology)
Hemodynamics
6-Ketoprostaglandin F1 alpha
Pharmacology
Methylprednisolone
chemistry.chemical_compound
Dogs
Animals
Medicine
Lung
Glycoproteins
General Veterinary
business.industry
Therapeutic effect
Ulinastatin
Shock, Septic
Thromboxane B2
chemistry
Shock (circulatory)
Anesthesia
medicine.symptom
Trypsin Inhibitors
business
medicine.drug
Subjects
Details
- ISSN :
- 13477439 and 09167250
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Medical Science
- Accession number :
- edsair.doi.dedup.....d3d174a66875a0eeb81d4da3847bcc65