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Antiviral immunity and nucleic acid sensing in haematopoietic stem cell gene engineering
- Source :
- Gene Therapy
- Publication Year :
- 2020
-
Abstract
- The low gene manipulation efficiency of human hematopoietic stem and progenitor cells (HSPC) remains a major hurdle for sustainable and broad clinical application of innovative therapies for a wide range of disorders. Given that all current and emerging gene transfer and editing technologies are bound to expose HSPC to exogenous nucleic acids and most often also to viral vectors, we reason that host antiviral factors and nucleic acid sensors play a pivotal role in the efficacy of HSPC genetic manipulation. Here, we review recent progress in our understanding of vector–host interactions and innate immunity in HSPC upon gene engineering and discuss how dissecting this crosstalk can guide the development of more stealth and efficient gene therapy approaches in the future.
- Subjects :
- Genetic enhancement
Genetic Vectors
Review Article
Computational biology
Biology
Antiviral Agents
Viral vector
03 medical and health sciences
0302 clinical medicine
Nucleic Acids
Genetics
Humans
Progenitor cell
Molecular Biology
Gene
030304 developmental biology
Innate immunity
0303 health sciences
Innate immune system
Haematopoietic stem cells
Genetic Therapy
Hematopoietic Stem Cells
3. Good health
Haematopoiesis
030220 oncology & carcinogenesis
Nucleic acid
Molecular Medicine
Stem cell
Subjects
Details
- ISSN :
- 09697128
- Database :
- OpenAIRE
- Journal :
- Gene Therapy
- Accession number :
- edsair.doi.dedup.....d3cffdd9f90c5afba723d683ddc26440
- Full Text :
- https://doi.org/10.1038/s41434-020-0175-3