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Nonselective β-Blockers May Progress the Thrombosis of Portal Venous System in Cirrhotic Patients: A Retrospective Observational Study
- Source :
- Advances in Therapy
- Publication Year :
- 2020
- Publisher :
- Adis, 2020.
-
Abstract
- Introduction Occlusive portal venous system thrombosis (PVT) is significantly associated with poor outcomes in cirrhotic patients. Nonselective β-blockers (NSBBs) may be associated with the development of PVT. However, the role of NSBBs in progressing thrombosis remains unclear. Methods Forty-three patients on whom contrast-enhanced computed tomography or magnetic resonance imaging was performed twice, and for whom there was detailed information regarding NSBBs, were eligible in this study, including 16 in the NSBBs group and 27 in the no NSBBs group. A composite endpoint of progressing thrombosis included the development of PVT in patients without PVT and aggravation of PVT in patients with PVT. Logistic regression analysis was employed to identify the effect of NSBBs on the progression of PVT. Results At the last admission, 13 patients had progressing thrombosis. The incidence of progressing thrombosis was significantly higher in the NSBBs group than in the no NSBBs group [50.0% (8/16) vs. 18.5% (5/27), P = 0.030]. The use of NSBBs (odds ratio 4.400, 95% confidence interval 1.107–17.482, P = 0.035) was significantly associated with progressing thrombosis in univariate logistic regression analyses, but not significant (odds ratio 4.084, 95% confidence interval 0.488–34.158, P = 0.194) in multivariate logistic regression analyses. Conclusions NSBBs may play a role in the progression of PVT in liver cirrhosis. The benefits and risks of NSBBs in the management of liver cirrhosis should be fully weighed.
- Subjects :
- Adult
Liver Cirrhosis
Male
030213 general clinical medicine
medicine.medical_specialty
Cirrhosis
Hepatorenal Syndrome
genetic structures
medicine.drug_class
Adrenergic beta-Antagonists
Portal venous system
Logistic regression
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
mental disorders
Hypertension, Portal
medicine
Humans
Pharmacology (medical)
Beta-blocker
Beta blocker
Retrospective Studies
Original Research
Venous Thrombosis
Progression
business.industry
Retrospective cohort study
Thrombosis
General Medicine
Odds ratio
Middle Aged
medicine.disease
Confidence interval
Settore MED/15 - MALATTIE DEL SANGUE
Portal vein
030220 oncology & carcinogenesis
Case-Control Studies
Disease Progression
Female
business
Tomography, X-Ray Computed
human activities
Liver Circulation
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Advances in Therapy
- Accession number :
- edsair.doi.dedup.....d39d169a1ce7024816ec5794f490aa60