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Associations between cerebral blood flow and structural and functional brain imaging measures in individuals with neuropsychologically defined mild cognitive impairment
- Source :
- Neurobiol Aging
- Publication Year :
- 2018
-
Abstract
- Reduced cerebral blood flow (CBF), an indicator of neurovascular processes and metabolic demands, is a common finding in Alzheimer's disease. However, little is known about what contributes to CBF deficits in individuals with mild cognitive impairment (MCI). We examine regional CBF differences in 17 MCI compared with 21 age-matched cognitively healthy older adults. Next, we examined associations between CBF, white matter lesion (WML) volume, amplitude of low-frequency fluctuations, and cortical thickness to better understand whether altered CBF was detectable before other markers and the potential mechanistic underpinnings of CBF deficits in MCI. MCI had significantly reduced CBF, whereas cortical thickness and amplitude of low-frequency fluctuation were not affected. Reduced CBF was associated with the WML volume but not associated with other measures. Given the presumed vascular etiology of WML and relative worsening of vascular health in MCI, it may suggest CBF deficits result from early vascular as opposed to metabolic deficits in MCI. These findings may support vascular mechanisms as an underlying component of cognitive impairment.
- Subjects :
- 0301 basic medicine
Male
Aging
medicine.medical_specialty
White matter lesion
Disease
Neuropsychological Tests
Article
Vascular health
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Internal medicine
medicine
Humans
Cognitive Dysfunction
Cognitive impairment
Aged
business.industry
General Neuroscience
Organ Size
Middle Aged
Magnetic Resonance Imaging
White Matter
Hyperintensity
Functional Brain Imaging
030104 developmental biology
Cerebral blood flow
nervous system
Cerebrovascular Circulation
Cardiology
cardiovascular system
Female
Neurology (clinical)
Geriatrics and Gerontology
business
human activities
030217 neurology & neurosurgery
Developmental Biology
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 15581497
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Neurobiology of aging
- Accession number :
- edsair.doi.dedup.....d39addc4d08ba566c0cc256295b3d152