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Discovery of 4-azaindoles as novel inhibitors of c-Met kinase
- Source :
- Bioorganicmedicinal chemistry letters. 19(10)
- Publication Year :
- 2009
-
Abstract
- A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development are discussed.
- Subjects :
- C-Met
Indoles
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Tumor cells
Crystallography, X-Ray
Biochemistry
chemistry.chemical_compound
Structure-Activity Relationship
Growth factor receptor
Cell Line, Tumor
Drug Discovery
Transferase
Humans
Computer Simulation
Molecular Biology
Protein Kinase Inhibitors
chemistry.chemical_classification
Kinase
Organic Chemistry
Proto-Oncogene Proteins c-met
Enzyme
chemistry
Molecular Medicine
Signal transduction
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 19
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....d3985a39d17773e1b2ec299ad573ae58