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Successful laparoscopic resection of virilizing ovarian steroid cell tumor, not otherwise specified, in a 22-year-old woman: a case report and evaluation of the steroidogenic pathway
- Source :
- FUKUSHIMA JOURNAL OF MEDICAL SCIENCE. 65:133-139
- Publication Year :
- 2019
- Publisher :
- The Fukushima Society of Medical Science, 2019.
-
Abstract
- OBJECTIVE: Ovarian steroid cell tumor (SCT) is a rare tumor with steroid-producing ability. We report a 22-year-old woman with secondary amenorrhea and hirsutism caused by an ovarian SCT-not otherwise specified (NOS), who underwent successfully laparoscopic resection of the tumor. CASE REPORT: A 22-year-old null gravida woman presented to a hospital, having amenorrhea for 18 months and increasing facial hair. Physical examination revealed obesity (body mass index, 37.3 kg/m(2)) with evident facial and trunk hair. Total and free serum testosterone, and dehydroepiandrosterone sulfate levels were found to be elevated. Levels of serum adrenocorticotropic hormone, gonadotropins, cortisol, aldosterone, and ovarian steroids were observed to be within reference intervals. Although polycystic ovaries were not found, a hyperechogenic solid tumor (3 cm) was detected on transvaginal ultrasonography. Laparoscopic resection of the tumor was performed. One month post-surgery, total and free testosterone levels were observed to have decreased, and menstruation resumed two months thereafter. The patient was histologically diagnosed with ovarian SCT-NOS. Expression of ovarian steroidogenic enzymes, which are related to hyperandrogenism, was observed. No disease recurrence has been reported for more than 5 years post-surgery.
- Subjects :
- steroid cell tumor not other specified
endocrine system
medicine.medical_specialty
Urology
Case Report
Adrenocorticotropic hormone
amenorrhea
hyperandrogenism
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Dehydroepiandrosterone sulfate
medicine
Humans
Testosterone
Ovarian Steroid Cell Tumor
hirsutism
Ovarian Neoplasms
business.industry
Hyperandrogenism
Not Otherwise Specified
General Medicine
medicine.disease
laparoscopic surgery
Virilism
Polycystic ovary
chemistry
030220 oncology & carcinogenesis
ovarian tumor
Female
Laparoscopy
Steroids
030211 gastroenterology & hepatology
Amenorrhea
medicine.symptom
business
Subjects
Details
- ISSN :
- 21854610 and 00162590
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- FUKUSHIMA JOURNAL OF MEDICAL SCIENCE
- Accession number :
- edsair.doi.dedup.....d395b64848ecab69c46de0b8e121b782